Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing.

Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing.

Here, we present evidence for a specific role of the splicing-related factor TCERG1 in regulating apoptosis in live cells by modulating the alternative splicing of the apoptotic genes Bcl-x and Fas. We show that TCERG1 modulates Bcl-x alternative splicing during apoptosis and its activity in Bcl-x a...

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Bibliographic Details
Main Authors: Marta Montes, Mayte Coiras, Soraya Becerra, Cristina Moreno-Castro, Elena Mateos, Jara Majuelos, F Javier Oliver, Cristina Hernández-Munain, José Alcamí, Carlos Suñé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139812&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139812&type=printable

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