Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Abstract Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and s...

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Bibliographic Details
Main Authors: Chensi Liang, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Zhenlei Chen, Dan Can, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
alzheimer's disease
BACE1
glycosylation
mannose
β‐amyloid
Online Access:https://doi.org/10.1002/advs.202409105
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