Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance.

Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance.

There is limited data on the clinical, cellular and molecular changes in relapsed acute promyeloytic leukemia (RAPL) in comparison with newly diagnosed cases (NAPL). We undertook a prospective study to compare NAPL and RAPL patients treated with arsenic trioxide (ATO) based regimens. 98 NAPL and 28...

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Main Authors: Ezhilarasi Chendamarai, Saravanan Ganesan, Ansu Abu Alex, Vandana Kamath, Sukesh C Nair, Arun Jose Nellickal, Nancy Beryl Janet, Vivi Srivastava, Kavitha M Lakshmi, Auro Viswabandya, Aby Abraham, Mohammed Aiyaz, Nandita Mullapudi, Raja Mugasimangalam, Rose Ann Padua, Christine Chomienne, Mammen Chandy, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0121912&type=printable
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