Modeling hepatic steatosis with human adult stem cell-derived liver organoids

Modeling hepatic steatosis with human adult stem cell-derived liver organoids

Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) remains the most common chronic liver disease worldwide, and appropriate in vitro models are of great significance for investigating pathogenesis and drug screening of MASLD. In this study, human expandable cholangiocyte organ...

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Bibliographic Details
Main Authors: Liuyang Zhu, Sen Liu, Ze Wang, Yueyue Yang, Pinsheng Han, Wen Tong, Tianyu Zhao, Libo Wang, Tao Cui, Long Yang, Yamin Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Disease
Human metabolism
Cellular physiology
Stem cells research
Organizational aspects of cell biology
Specialized functions of cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006054
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