Antidiabetic Potential of Marine Brown Algae—a Mini Review
Marine algae are an important source of bioactive metabolites in drug development and nutraceuticals. Diabetes mellitus is a metabolic disorder and the third leading cause of death worldwide due to lifestyle changes associated with rapid urbanization. Due to the adverse side effects of currently ava...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/1230218 |
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| author | Thilina L. Gunathilaka Kalpa Samarakoon Pathmasiri Ranasinghe L. Dinithi C. Peiris |
| author_facet | Thilina L. Gunathilaka Kalpa Samarakoon Pathmasiri Ranasinghe L. Dinithi C. Peiris |
| author_sort | Thilina L. Gunathilaka |
| collection | DOAJ |
| description | Marine algae are an important source of bioactive metabolites in drug development and nutraceuticals. Diabetes mellitus is a metabolic disorder and the third leading cause of death worldwide due to lifestyle changes associated with rapid urbanization. Due to the adverse side effects of currently available antidiabetic drugs, search for an effective natural-based antidiabetic drug is important to combat diabetes and its complications. Therefore, in lieu with herbal drug development, it is important to find the potential benefits of seaweeds for the management of type 2 diabetes as they are underexplored yet in Sri Lanka. Among the marine seaweeds, natural bioactive compounds are abundant in brown algae with potentials in application as active ingredients in drug leads and nutraceuticals. Bioactive secondary metabolites are derived from numerous biosynthetic pathways of marine algae which contribute to various chemical and biological properties. Phlorotannins present in marine brown algae exhibited antidiabetic activities through different mechanisms such as the inhibitory effect of enzyme targets mainly by inhibiting the enzymes such as α-amylase, α-glucosidase, angiotensin-converting enzymes (ACE), aldose reductase, dipeptidyl peptidase-4, and protein tyrosine phosphatase 1B (PTP 1B) enzyme. In addition, phlorotannins derived from brown algae have the ability to reduce diabetic complications. Hence, the present review focuses on the different antidiabetic mechanisms of secondary bioactive compounds present in marine brown algae. |
| format | Article |
| id | doaj-art-df2d346a506e45d2b5ad42ddf10ccc4e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-df2d346a506e45d2b5ad42ddf10ccc4e2025-02-03T01:25:17ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/12302181230218Antidiabetic Potential of Marine Brown Algae—a Mini ReviewThilina L. Gunathilaka0Kalpa Samarakoon1Pathmasiri Ranasinghe2L. Dinithi C. Peiris3Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda 10250, Sri LankaNational Science and Technology Commission, Dudley Senanayake Mawatha, Colombo 8 00800, Sri LankaIndustrial Technology Institute, Halbarawa Gardens, Malabe 10115, Sri LankaDepartment of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda 10250, Sri LankaMarine algae are an important source of bioactive metabolites in drug development and nutraceuticals. Diabetes mellitus is a metabolic disorder and the third leading cause of death worldwide due to lifestyle changes associated with rapid urbanization. Due to the adverse side effects of currently available antidiabetic drugs, search for an effective natural-based antidiabetic drug is important to combat diabetes and its complications. Therefore, in lieu with herbal drug development, it is important to find the potential benefits of seaweeds for the management of type 2 diabetes as they are underexplored yet in Sri Lanka. Among the marine seaweeds, natural bioactive compounds are abundant in brown algae with potentials in application as active ingredients in drug leads and nutraceuticals. Bioactive secondary metabolites are derived from numerous biosynthetic pathways of marine algae which contribute to various chemical and biological properties. Phlorotannins present in marine brown algae exhibited antidiabetic activities through different mechanisms such as the inhibitory effect of enzyme targets mainly by inhibiting the enzymes such as α-amylase, α-glucosidase, angiotensin-converting enzymes (ACE), aldose reductase, dipeptidyl peptidase-4, and protein tyrosine phosphatase 1B (PTP 1B) enzyme. In addition, phlorotannins derived from brown algae have the ability to reduce diabetic complications. Hence, the present review focuses on the different antidiabetic mechanisms of secondary bioactive compounds present in marine brown algae.http://dx.doi.org/10.1155/2020/1230218 |
| spellingShingle | Thilina L. Gunathilaka Kalpa Samarakoon Pathmasiri Ranasinghe L. Dinithi C. Peiris Antidiabetic Potential of Marine Brown Algae—a Mini Review Journal of Diabetes Research |
| title | Antidiabetic Potential of Marine Brown Algae—a Mini Review |
| title_full | Antidiabetic Potential of Marine Brown Algae—a Mini Review |
| title_fullStr | Antidiabetic Potential of Marine Brown Algae—a Mini Review |
| title_full_unstemmed | Antidiabetic Potential of Marine Brown Algae—a Mini Review |
| title_short | Antidiabetic Potential of Marine Brown Algae—a Mini Review |
| title_sort | antidiabetic potential of marine brown algae a mini review |
| url | http://dx.doi.org/10.1155/2020/1230218 |
| work_keys_str_mv | AT thilinalgunathilaka antidiabeticpotentialofmarinebrownalgaeaminireview AT kalpasamarakoon antidiabeticpotentialofmarinebrownalgaeaminireview AT pathmasiriranasinghe antidiabeticpotentialofmarinebrownalgaeaminireview AT ldinithicpeiris antidiabeticpotentialofmarinebrownalgaeaminireview |