Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress
This study was designed to investigate whether Petroselinum crispum (PC) extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease (AD) rat model. The rats were divided into; control, scopolamine (1 mg/kg, i.p.), galantamine (1.5 mg/kg, i.p.) and PC extract (2 g/kg,...
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000477 |
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| author | Göksel Şener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac |
| author_facet | Göksel Şener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac |
| author_sort | Göksel Şener |
| collection | DOAJ |
| description | This study was designed to investigate whether Petroselinum crispum (PC) extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease (AD) rat model. The rats were divided into; control, scopolamine (1 mg/kg, i.p.), galantamine (1.5 mg/kg, i.p.) and PC extract (2 g/kg, p.o.)-treated scopolamine groups. On day 14, the novel object recognition test (NORT) and Morris water maze test (MWMT) were performed and then the rats were sacrificed. Scopolamine-induced cognitive impairments observed in the NORT and MWMT, significantly improved with PC extract and galantamine treatments. Scopolamine reduced M1 receptor expression, Bcl-2/Bax ratio, and glutathione levels in the hippocampus and frontal cortex, while malondialdehyde levels, caspase-3/9 expressions, and acetylcholinesterase (AChE) activity were found to be increased. On the other hand, PC and galantamine treatments reversed these changes. In conclusion, PC extract has shown an ameliorative effect on the spatial and recognition memory, M1 receptor expression, apoptosis, oxidative stress, and increased AChE activity. Thus, it was concluded that PC could prevent AD-like conditions and can be used as a functional food. However, since animal models do not completely mimic those of humans, based on the data obtained in this study, the importance of PC on human AD should be demonstrated in future studies. |
| format | Article |
| id | doaj-art-df28a4f2c12842c6a10952de175b7830 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-df28a4f2c12842c6a10952de175b78302025-02-03T02:27:47ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111512901298Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stressGöksel Şener0Gözde Karakadıoglu1Dilek Ozbeyli2Seren Ede3Refiye Yanardag4Ozlem Sacan5Asli Aykac6Department of Pharmacology, Faculty of Pharmacy, Fenerbahce University, Istanbul 34758, Turkey; Corresponding author at: Department of Pharmacology, Faculty of Pharmacy, Fenerbahce University, Istanbul, 34758 Turkey.Department of Pharmacology, Institude of Health Sciences, Marmara University, Istanbul 34854, TurkeyDepartment of Medical Pathology Techniques, Vocational School of Health Services, Marmara University, Istanbul 34865, TurkeyDepartment of Pharmacology, Institude of Health Sciences, Marmara University, Istanbul 34854, TurkeyDepartment of Biochemistry, Faculty of Engineering, Istanbul Universityş-Cerrahpasa, Istanbul 34320, TurkeyDepartment of Biochemistry, Faculty of Engineering, Istanbul Universityş-Cerrahpasa, Istanbul 34320, TurkeyDepartment of Biophysics, Faculty of Medicine, Near East University, Nicosia 99138, CyprusThis study was designed to investigate whether Petroselinum crispum (PC) extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease (AD) rat model. The rats were divided into; control, scopolamine (1 mg/kg, i.p.), galantamine (1.5 mg/kg, i.p.) and PC extract (2 g/kg, p.o.)-treated scopolamine groups. On day 14, the novel object recognition test (NORT) and Morris water maze test (MWMT) were performed and then the rats were sacrificed. Scopolamine-induced cognitive impairments observed in the NORT and MWMT, significantly improved with PC extract and galantamine treatments. Scopolamine reduced M1 receptor expression, Bcl-2/Bax ratio, and glutathione levels in the hippocampus and frontal cortex, while malondialdehyde levels, caspase-3/9 expressions, and acetylcholinesterase (AChE) activity were found to be increased. On the other hand, PC and galantamine treatments reversed these changes. In conclusion, PC extract has shown an ameliorative effect on the spatial and recognition memory, M1 receptor expression, apoptosis, oxidative stress, and increased AChE activity. Thus, it was concluded that PC could prevent AD-like conditions and can be used as a functional food. However, since animal models do not completely mimic those of humans, based on the data obtained in this study, the importance of PC on human AD should be demonstrated in future studies.http://www.sciencedirect.com/science/article/pii/S2213453022000477Petroselinum crispumApoptosisSpatial memoryRecognition memoryOxidative stressM1 receptor |
| spellingShingle | Göksel Şener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress Food Science and Human Wellness Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor |
| title | Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress |
| title_full | Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress |
| title_fullStr | Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress |
| title_full_unstemmed | Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress |
| title_short | Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress |
| title_sort | petroselinum crispum extract ameliorates scopolamine induced cognitive dysfunction role on apoptosis inflammation and oxidative stress |
| topic | Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000477 |
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