Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target
Asthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. I...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3743048 |
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| _version_ | 1832549963722129408 |
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| author | Han Gao Songmin Ying Yuanrong Dai |
| author_facet | Han Gao Songmin Ying Yuanrong Dai |
| author_sort | Han Gao |
| collection | DOAJ |
| description | Asthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines. In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma. This review discusses neutrophils in asthma and potentially related targeted therapies. |
| format | Article |
| id | doaj-art-df0032e2d19c456490235c7426b3d594 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-df0032e2d19c456490235c7426b3d5942025-02-03T06:08:11ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/37430483743048Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a TargetHan Gao0Songmin Ying1Yuanrong Dai2Department of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaAsthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines. In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma. This review discusses neutrophils in asthma and potentially related targeted therapies.http://dx.doi.org/10.1155/2017/3743048 |
| spellingShingle | Han Gao Songmin Ying Yuanrong Dai Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target Journal of Immunology Research |
| title | Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target |
| title_full | Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target |
| title_fullStr | Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target |
| title_full_unstemmed | Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target |
| title_short | Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target |
| title_sort | pathological roles of neutrophil mediated inflammation in asthma and its potential for therapy as a target |
| url | http://dx.doi.org/10.1155/2017/3743048 |
| work_keys_str_mv | AT hangao pathologicalrolesofneutrophilmediatedinflammationinasthmaanditspotentialfortherapyasatarget AT songminying pathologicalrolesofneutrophilmediatedinflammationinasthmaanditspotentialfortherapyasatarget AT yuanrongdai pathologicalrolesofneutrophilmediatedinflammationinasthmaanditspotentialfortherapyasatarget |