Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study
Purpose. Determine patient-reported reasons for discontinuation with teriparatide. Methods. Patients taking teriparatide in a multicenter, prospective, and observational study were given three questionnaires: baseline, follow-up questionnaire 1 (QF1, 2 to 6 months), and follow-up questionnaire 2 (QF...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/314970 |
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| _version_ | 1832545608621096960 |
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| author | Deborah T. Gold David L. Weinstein Gerhardt Pohl Kelly D. Krohn Yi Chen Eric S. Meadows |
| author_facet | Deborah T. Gold David L. Weinstein Gerhardt Pohl Kelly D. Krohn Yi Chen Eric S. Meadows |
| author_sort | Deborah T. Gold |
| collection | DOAJ |
| description | Purpose. Determine patient-reported reasons for discontinuation with teriparatide. Methods. Patients taking teriparatide in a multicenter, prospective, and observational study were given three questionnaires: baseline, follow-up questionnaire 1 (QF1, 2 to 6 months), and follow-up questionnaire 2 (QF2, 12 months). Discontinuation reported at QF1 and QF2 was defined as “early” and “late,” respectively, and remaining patients were considered persistent. Cochran-Armitage trend test was used to identify factors associated with discontinuation. Results. Side effects, concern about improper use, injection difficulties, and several patient-perceived physician issues were associated with early discontinuation. Low patient-perceived importance of continuing treatment, side effects, difficulty paying, and low patient-perceived physician knowledge were associated with late discontinuation. The most common specific reasons selected for discontinuing treatment were “concerns about treatment outweighing the benefits” (n=53) and “difficulty paying” (n=47). Conclusions. Persistence with teriparatide is dependent on managing side effects, addressing financial challenges, proper training, and obtaining support from the healthcare provider. |
| format | Article |
| id | doaj-art-defd34d9999e47e7849e25aba9d21844 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-defd34d9999e47e7849e25aba9d218442025-02-03T07:25:21ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/314970314970Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational StudyDeborah T. Gold0David L. Weinstein1Gerhardt Pohl2Kelly D. Krohn3Yi Chen4Eric S. Meadows5Departments of Psychiatry and Behavioral Sciences, Sociology, and Psychology and Neuroscience, Duke University Medical Center, Durham, NC 27710, USAWashington University School of Medicine, St. Louis, MO 63110, USALilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USALilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USALilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USALilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USAPurpose. Determine patient-reported reasons for discontinuation with teriparatide. Methods. Patients taking teriparatide in a multicenter, prospective, and observational study were given three questionnaires: baseline, follow-up questionnaire 1 (QF1, 2 to 6 months), and follow-up questionnaire 2 (QF2, 12 months). Discontinuation reported at QF1 and QF2 was defined as “early” and “late,” respectively, and remaining patients were considered persistent. Cochran-Armitage trend test was used to identify factors associated with discontinuation. Results. Side effects, concern about improper use, injection difficulties, and several patient-perceived physician issues were associated with early discontinuation. Low patient-perceived importance of continuing treatment, side effects, difficulty paying, and low patient-perceived physician knowledge were associated with late discontinuation. The most common specific reasons selected for discontinuing treatment were “concerns about treatment outweighing the benefits” (n=53) and “difficulty paying” (n=47). Conclusions. Persistence with teriparatide is dependent on managing side effects, addressing financial challenges, proper training, and obtaining support from the healthcare provider.http://dx.doi.org/10.4061/2011/314970 |
| spellingShingle | Deborah T. Gold David L. Weinstein Gerhardt Pohl Kelly D. Krohn Yi Chen Eric S. Meadows Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study Journal of Osteoporosis |
| title | Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study |
| title_full | Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study |
| title_fullStr | Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study |
| title_full_unstemmed | Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study |
| title_short | Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study |
| title_sort | factors associated with persistence with teriparatide therapy results from the dance observational study |
| url | http://dx.doi.org/10.4061/2011/314970 |
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