Azelastine and suplatast shorten the distribution half-life of IgE in rats
We aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of immunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 days after the first sensitization. T...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350210310 |
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| author | Kazuhiko Hanashiro Yoshihiro Tokeshi Toshiyuki Nakasone Masanori Sunagawa Mariko Nakamura Tadayoshi Kosugi |
| author_facet | Kazuhiko Hanashiro Yoshihiro Tokeshi Toshiyuki Nakasone Masanori Sunagawa Mariko Nakamura Tadayoshi Kosugi |
| author_sort | Kazuhiko Hanashiro |
| collection | DOAJ |
| description | We aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of immunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 days after the first sensitization. Two milligrams of monoclonal dinitrophenyl (DNP)-specific rat IgE was administered to the rats, which had been given suplatast or azelastine orally. The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. The elimination half-life of rat IgE was about 12 h irrespective of the sensitized state. The intercompartmental rate constants (Kct
and
Ktc) in the suplatast-administered or azelastine-administered group were larger than those of the distilled water-administered group under non-sensitized conditions. These findings suggested that the anti-allergic drugs used in the present study facilitated the excretion of IgE from the circulation in rats. |
| format | Article |
| id | doaj-art-de91d42c64994f78ade1e2c6c7f8c767 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-de91d42c64994f78ade1e2c6c7f8c7672025-02-03T01:26:47ZengWileyMediators of Inflammation0962-93511466-18612002-01-01111616410.1080/09629350210310Azelastine and suplatast shorten the distribution half-life of IgE in ratsKazuhiko Hanashiro0Yoshihiro Tokeshi1Toshiyuki Nakasone2Masanori Sunagawa3Mariko Nakamura4Tadayoshi Kosugi51st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, Japan1st Department of Physiology, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903–0215, JapanWe aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of immunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 days after the first sensitization. Two milligrams of monoclonal dinitrophenyl (DNP)-specific rat IgE was administered to the rats, which had been given suplatast or azelastine orally. The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. The elimination half-life of rat IgE was about 12 h irrespective of the sensitized state. The intercompartmental rate constants (Kct and Ktc) in the suplatast-administered or azelastine-administered group were larger than those of the distilled water-administered group under non-sensitized conditions. These findings suggested that the anti-allergic drugs used in the present study facilitated the excretion of IgE from the circulation in rats.http://dx.doi.org/10.1080/09629350210310 |
| spellingShingle | Kazuhiko Hanashiro Yoshihiro Tokeshi Toshiyuki Nakasone Masanori Sunagawa Mariko Nakamura Tadayoshi Kosugi Azelastine and suplatast shorten the distribution half-life of IgE in rats Mediators of Inflammation |
| title | Azelastine and suplatast shorten the distribution half-life of IgE in rats |
| title_full | Azelastine and suplatast shorten the distribution half-life of IgE in rats |
| title_fullStr | Azelastine and suplatast shorten the distribution half-life of IgE in rats |
| title_full_unstemmed | Azelastine and suplatast shorten the distribution half-life of IgE in rats |
| title_short | Azelastine and suplatast shorten the distribution half-life of IgE in rats |
| title_sort | azelastine and suplatast shorten the distribution half life of ige in rats |
| url | http://dx.doi.org/10.1080/09629350210310 |
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