R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia
A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget’s disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with rad...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/9764049 |
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| author | Alay Mansurov Eric Christenson |
| author_facet | Alay Mansurov Eric Christenson |
| author_sort | Alay Mansurov |
| collection | DOAJ |
| description | A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget’s disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with radiation to his lower extremities. MRI confirmed vertebral metastasis. Despite surgical and radiation therapy, his back pain progressed, and repeat imaging showed epidural spread of tumor in the thoracic spine. Later, the patient was admitted to the hospital due to severe anemia and thrombocytopenia. Further work-up confirmed the diagnosis of microangiopathic hemolytic anemia (MAHA). As we know, there are only few reports of spinal metastases in patients with EMPD. To the best of our knowledge, this is the first case report of EMPD complicated by MAHA. |
| format | Article |
| id | doaj-art-de8b2e0cc1c64dbb9bba8216bb45c1c6 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-de8b2e0cc1c64dbb9bba8216bb45c1c62025-02-03T01:12:16ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/97640499764049R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic AnemiaAlay Mansurov0Eric Christenson1Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USASection of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at John Hopkins Hospital, Baltimore, MD, USAA 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget’s disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with radiation to his lower extremities. MRI confirmed vertebral metastasis. Despite surgical and radiation therapy, his back pain progressed, and repeat imaging showed epidural spread of tumor in the thoracic spine. Later, the patient was admitted to the hospital due to severe anemia and thrombocytopenia. Further work-up confirmed the diagnosis of microangiopathic hemolytic anemia (MAHA). As we know, there are only few reports of spinal metastases in patients with EMPD. To the best of our knowledge, this is the first case report of EMPD complicated by MAHA.http://dx.doi.org/10.1155/2018/9764049 |
| spellingShingle | Alay Mansurov Eric Christenson R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia Case Reports in Hematology |
| title | R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia |
| title_full | R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia |
| title_fullStr | R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia |
| title_full_unstemmed | R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia |
| title_short | R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia |
| title_sort | r inguinal r scrotum extramammary paget s disease with diffuse spine metastasis complicated by microangiopathic hemolytic anemia |
| url | http://dx.doi.org/10.1155/2018/9764049 |
| work_keys_str_mv | AT alaymansurov ringuinalrscrotumextramammarypagetsdiseasewithdiffusespinemetastasiscomplicatedbymicroangiopathichemolyticanemia AT ericchristenson ringuinalrscrotumextramammarypagetsdiseasewithdiffusespinemetastasiscomplicatedbymicroangiopathichemolyticanemia |