Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications
Abstract Most wearable biosensors aimed at capturing psychological state target stress biomarkers in the form of physical symptoms that can correlate with dysfunction in the central nervous system (CNS). However, such markers lack the specificity needed for diagnostic or preventative applications. W...
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Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411339 |
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| author | Zach Sheffield Priyanka Paul Shraddha Krishnakumar Dipanjan Pan |
| author_facet | Zach Sheffield Priyanka Paul Shraddha Krishnakumar Dipanjan Pan |
| author_sort | Zach Sheffield |
| collection | DOAJ |
| description | Abstract Most wearable biosensors aimed at capturing psychological state target stress biomarkers in the form of physical symptoms that can correlate with dysfunction in the central nervous system (CNS). However, such markers lack the specificity needed for diagnostic or preventative applications. Wearable biochemical sensors (WBSs) have the potential to fill this gap, however, the technology is still in its infancy. Most WBSs proposed thus far target cortisol. Although cortisol detection is demonstrated as a viable method for approximating the extent and severity of psychological stress, the hormone also lacks specificity. Multiplex WBSs that simultaneously target cortisol alongside other viable stress‐related biochemical markers (SBMs) can prove to be indispensable for understanding how psychological stress contributes to the pathophysiology of neuropsychiatric illnesses (NPIs) and, thus, lead to the discovery of new biomarkers and more objective clinical tools. However, none target more than one SBM implicated in NPIs. Till this review, cortisol's connection to dysfunctions in the CNS, to other SBMs, and their implication in various NPIs has not been discussed in the context of developing WBS technology. As such, this review is meant to inform the biosensing and neuropsychiatric communities of viable future directions and possible challenges for WBS technology for neuropsychiatric applications. |
| format | Article |
| id | doaj-art-de77bd15e73443ce95ca858b6234509f |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-de77bd15e73443ce95ca858b6234509f2025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202411339Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric ApplicationsZach Sheffield0Priyanka Paul1Shraddha Krishnakumar2Dipanjan Pan3Huck Institutes of the Life Sciences The Pennsylvania State University State College PA 16802 USADepartment of Pediatrics University of Maryland Baltimore School of Medicine Baltimore MD 21201 USAHuck Institutes of the Life Sciences The Pennsylvania State University State College PA 16802 USAHuck Institutes of the Life Sciences The Pennsylvania State University State College PA 16802 USAAbstract Most wearable biosensors aimed at capturing psychological state target stress biomarkers in the form of physical symptoms that can correlate with dysfunction in the central nervous system (CNS). However, such markers lack the specificity needed for diagnostic or preventative applications. Wearable biochemical sensors (WBSs) have the potential to fill this gap, however, the technology is still in its infancy. Most WBSs proposed thus far target cortisol. Although cortisol detection is demonstrated as a viable method for approximating the extent and severity of psychological stress, the hormone also lacks specificity. Multiplex WBSs that simultaneously target cortisol alongside other viable stress‐related biochemical markers (SBMs) can prove to be indispensable for understanding how psychological stress contributes to the pathophysiology of neuropsychiatric illnesses (NPIs) and, thus, lead to the discovery of new biomarkers and more objective clinical tools. However, none target more than one SBM implicated in NPIs. Till this review, cortisol's connection to dysfunctions in the CNS, to other SBMs, and their implication in various NPIs has not been discussed in the context of developing WBS technology. As such, this review is meant to inform the biosensing and neuropsychiatric communities of viable future directions and possible challenges for WBS technology for neuropsychiatric applications.https://doi.org/10.1002/advs.202411339cortisolmultiplexneuropsychiatricperipheral biofluidsstresswearable biosensors |
| spellingShingle | Zach Sheffield Priyanka Paul Shraddha Krishnakumar Dipanjan Pan Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications Advanced Science cortisol multiplex neuropsychiatric peripheral biofluids stress wearable biosensors |
| title | Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications |
| title_full | Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications |
| title_fullStr | Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications |
| title_full_unstemmed | Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications |
| title_short | Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications |
| title_sort | current strategies and future directions of wearable biosensors for measuring stress biochemical markers for neuropsychiatric applications |
| topic | cortisol multiplex neuropsychiatric peripheral biofluids stress wearable biosensors |
| url | https://doi.org/10.1002/advs.202411339 |
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