Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report
Primary Breast Lymphoma (PBL) is an uncommon form of Non Hodgkin Lymphoma (NHL) that arises within the breast tissue, representing less than 1-2% of all cases of NHL and under 0.5% of all breast cancers. Most PBL cases are of the B-cell type, accounting for up to 50% of all PBL. Diffuse Large B-cell...
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JCDR Research and Publications Private Limited
2025-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/20503/76054_CE[Ra1]_F(SHU)_QC(PS_OM)_PF1(AG_SS)_PFA_NC(IS)_PN(IS).pdf |
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| author | Sneha Samir Babaria Jinalben Shaileshbhai Patel |
| author_facet | Sneha Samir Babaria Jinalben Shaileshbhai Patel |
| author_sort | Sneha Samir Babaria |
| collection | DOAJ |
| description | Primary Breast Lymphoma (PBL) is an uncommon form of Non Hodgkin Lymphoma (NHL) that arises within the breast tissue, representing less than 1-2% of all cases of NHL and under 0.5% of all breast cancers. Most PBL cases are of the B-cell type, accounting for up to 50% of all PBL. Diffuse Large B-cell Lymphoma (DLBCL) of the breast is a rare subtype of NHL, with a common age of presentation in females being 50-60 years. It typically presents as a painless breast mass without pathognomonic radiologic findings. Authors hereby, report a case of a 43-year-old female who complained only of heaviness in the right breast, followed by a discretely palpable lump upon examination. High-grade NHL was diagnosed via core needle biopsy and turned out to be DLBCL, Activated B-cell (ABC)-like subtype, as determined by Immunohistochemistry (IHC). This study emphasises that histopathological analysis of core needle biopsy with IHC is paramount for establishing the diagnosis and distinguishing it from other benign and malignant breast conditions. By sharing this case, authors aimed to contribute to the growing knowledge of this rare entity, which has steadily increased over the past four decades, to ensure timely and accurate diagnosis for the implementation of appropriate therapy. |
| format | Article |
| id | doaj-art-de591a75a94a44a1b0de199420ec41f6 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-de591a75a94a44a1b0de199420ec41f62025-01-20T11:35:05ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901010310.7860/JCDR/2025/76054.20503Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case ReportSneha Samir Babaria0Jinalben Shaileshbhai Patel1Associate Professor, Department of Pathology, Dr. N. D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India.Senior Resident, Department of Pathology, Narendra Modi Medical College, Maninagar, Ahmedabad, Gujarat, India.Primary Breast Lymphoma (PBL) is an uncommon form of Non Hodgkin Lymphoma (NHL) that arises within the breast tissue, representing less than 1-2% of all cases of NHL and under 0.5% of all breast cancers. Most PBL cases are of the B-cell type, accounting for up to 50% of all PBL. Diffuse Large B-cell Lymphoma (DLBCL) of the breast is a rare subtype of NHL, with a common age of presentation in females being 50-60 years. It typically presents as a painless breast mass without pathognomonic radiologic findings. Authors hereby, report a case of a 43-year-old female who complained only of heaviness in the right breast, followed by a discretely palpable lump upon examination. High-grade NHL was diagnosed via core needle biopsy and turned out to be DLBCL, Activated B-cell (ABC)-like subtype, as determined by Immunohistochemistry (IHC). This study emphasises that histopathological analysis of core needle biopsy with IHC is paramount for establishing the diagnosis and distinguishing it from other benign and malignant breast conditions. By sharing this case, authors aimed to contribute to the growing knowledge of this rare entity, which has steadily increased over the past four decades, to ensure timely and accurate diagnosis for the implementation of appropriate therapy.https://jcdr.net/articles/PDF/20503/76054_CE[Ra1]_F(SHU)_QC(PS_OM)_PF1(AG_SS)_PFA_NC(IS)_PN(IS).pdfbreast lymphomanon hodgkin lymphomaprimary breast lymphoma |
| spellingShingle | Sneha Samir Babaria Jinalben Shaileshbhai Patel Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report Journal of Clinical and Diagnostic Research breast lymphoma non hodgkin lymphoma primary breast lymphoma |
| title | Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report |
| title_full | Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report |
| title_fullStr | Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report |
| title_full_unstemmed | Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report |
| title_short | Breast Diffuse Large B-cell Lymphoma, Activated B-cell like Subtype: A Case Report |
| title_sort | breast diffuse large b cell lymphoma activated b cell like subtype a case report |
| topic | breast lymphoma non hodgkin lymphoma primary breast lymphoma |
| url | https://jcdr.net/articles/PDF/20503/76054_CE[Ra1]_F(SHU)_QC(PS_OM)_PF1(AG_SS)_PFA_NC(IS)_PN(IS).pdf |
| work_keys_str_mv | AT snehasamirbabaria breastdiffuselargebcelllymphomaactivatedbcelllikesubtypeacasereport AT jinalbenshaileshbhaipatel breastdiffuselargebcelllymphomaactivatedbcelllikesubtypeacasereport |