Suppression of the LKB1-AMPK-SLC7A11-GSH signaling pathway sensitizes NSCLC to albumin-bound paclitaxel via oxidative stress

Suppression of the LKB1-AMPK-SLC7A11-GSH signaling pathway sensitizes NSCLC to albumin-bound paclitaxel via oxidative stress

Albumin-bound paclitaxel (nab-PTX) is an important chemotherapeutic drug used for the treatment of advanced and metastatic non-small cell lung cancer (NSCLC). One critical issue in its clinical application is the development of resistance; thus, a deeper understanding of the mechanisms underlying th...

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Bibliographic Details
Main Authors: Dade Rong, Liangliang Gao, Yiguan Chen, Xiang-Zheng Gao, Mingzhu Tang, Haimei Tang, Yuan Gao, Guang Lu, Zhi-Qiang Ling, Han-Ming Shen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Albumin-bound paclitaxel
LKB1
Non-small lung cancer
AMPK
SLC7A11
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000801
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