The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling

The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling

Abstract K2P2.1 (gene: Kcnk2), a two-pore-domain potassium channel, regulates leukocyte transmigration across the blood-brain barrier by a yet unknown mechanism. We demonstrate that Kcnk2 −/− mouse brain microvascular endothelial cells (MBMECs) exhibit an altered cytoskeletal structure and surface m...

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Main Authors: Stefanie Lichtenberg, Laura Vinnenberg, Falk Steffen, Isabelle Plegge, Nicholas Hanuscheck, Vera Dobelmann, Joel Gruchot, Christina B. Schroeter, Haribaskar Ramachandran, Beatrice Wasser, Derya Bachir, Christopher Nelke, Jonas Franz, Christoph Riethmüller, Stefan Tenzer, Ute Distler, Christina Francisca Vogelaar, Kristina Kusche-Vihrog, Boris V. Skryabin, Timofey S. Rozhdestvensky, Albrecht Schwab, Jean Krutmann, Andrea Rossi, Thomas Budde, Stefan Bittner, Sven G. Meuth, Tobias Ruck
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61816-9
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https://doi.org/10.1038/s41467-025-61816-9

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