Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer

Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer

Abstract Background Pancreatic cancer is a highly lethal malignancy with limited treatment response. Despite advancements in treatment, systemic chemotherapy remains the primary therapeutic approach for over 80% of patients, with no established biomarkers to guide drug selection. Traditional two-dim...

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Main Authors: Jin Su Kim, Chan Hee Park, Eunyoung Kim, Hee Seung Lee, Jinyoung Lee, Jeehoon Kim, Eun Hee Kam, Sanghee Nam, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Sangwoo Kim, Galam Leem, Seungmin Bang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
Conditionally reprogrammed cell (CRC) organoids
3D organoid culture
Drug sensitivity screening
Precision medicine
Gemcitabine plus nab-paclitaxel (Abraxane)
Online Access:https://doi.org/10.1186/s12943-025-02374-y
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https://doi.org/10.1186/s12943-025-02374-y

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