Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion
Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, and osteogenesis. Herein, a phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regenera...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-02-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400408 |
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| author | Liguo Zhang Zhao Li Yajing Fu Haoyang Tian Ting Wang Hongrui Liu Jianhua Li Hong Liu Shaohua Ge Baojin Ma |
| author_facet | Liguo Zhang Zhao Li Yajing Fu Haoyang Tian Ting Wang Hongrui Liu Jianhua Li Hong Liu Shaohua Ge Baojin Ma |
| author_sort | Liguo Zhang |
| collection | DOAJ |
| description | Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, and osteogenesis. Herein, a phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. By harnessing distinct modes of ion delivery, Cu2+ adsorbed on the surface can be released quickly from the CSHP membrane to trigger a cascade of events including antibacterial reaction, regulating macrophage polarization, and enhancing angiogenesis. With the gradual degradation of HAp, Sr2+ doped in the lattice is sustainably released, synergistically regulating immunity, and encouraging the genesis of robust skeletal tissue. The bilayer structure of the CSHP membrane also ensures the oriented release of bioactive ions to the bone defect area, circumventing any systemic complications that might arise from indiscriminate dispersal. Furthermore, the nanoengineered HAp layer deters pathogenic colonization due to the low adhesion force, which can effectively prevent the formation of bacterial biofilms and infection after implantation. Overall, the multifunctional bilayer CSHP membrane, based on the phased and oriented ions release, adapts to the dynamic requirements of bone repair, thereby augmenting regeneration efficiency, and also providing a reference for the design of advanced repair materials. |
| format | Article |
| id | doaj-art-ddd68552b79245f3beedd102b0a0cec9 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-ddd68552b79245f3beedd102b0a0cec92025-02-04T08:10:21ZengWiley-VCHSmall Structures2688-40622025-02-0162n/an/a10.1002/sstr.202400408Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial AdhesionLiguo Zhang0Zhao Li1Yajing Fu2Haoyang Tian3Ting Wang4Hongrui Liu5Jianhua Li6Hong Liu7Shaohua Ge8Baojin Ma9Department of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaState Key Laboratory of Crystal Materials Shandong University Jinan Shandong 250100 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaDepartment of Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration, Shandong Provincial Clinical Research Center for Oral Diseases Jinan Shandong 250012 ChinaBone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, and osteogenesis. Herein, a phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. By harnessing distinct modes of ion delivery, Cu2+ adsorbed on the surface can be released quickly from the CSHP membrane to trigger a cascade of events including antibacterial reaction, regulating macrophage polarization, and enhancing angiogenesis. With the gradual degradation of HAp, Sr2+ doped in the lattice is sustainably released, synergistically regulating immunity, and encouraging the genesis of robust skeletal tissue. The bilayer structure of the CSHP membrane also ensures the oriented release of bioactive ions to the bone defect area, circumventing any systemic complications that might arise from indiscriminate dispersal. Furthermore, the nanoengineered HAp layer deters pathogenic colonization due to the low adhesion force, which can effectively prevent the formation of bacterial biofilms and infection after implantation. Overall, the multifunctional bilayer CSHP membrane, based on the phased and oriented ions release, adapts to the dynamic requirements of bone repair, thereby augmenting regeneration efficiency, and also providing a reference for the design of advanced repair materials.https://doi.org/10.1002/sstr.202400408antibacterial adhesionbilayer structurebioactive metal ionsguided bone regenerationphased release |
| spellingShingle | Liguo Zhang Zhao Li Yajing Fu Haoyang Tian Ting Wang Hongrui Liu Jianhua Li Hong Liu Shaohua Ge Baojin Ma Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion Small Structures antibacterial adhesion bilayer structure bioactive metal ions guided bone regeneration phased release |
| title | Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion |
| title_full | Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion |
| title_fullStr | Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion |
| title_full_unstemmed | Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion |
| title_short | Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion |
| title_sort | phased ions release bilayer guided bone regeneration membrane with nanostructure mediated antibacterial adhesion |
| topic | antibacterial adhesion bilayer structure bioactive metal ions guided bone regeneration phased release |
| url | https://doi.org/10.1002/sstr.202400408 |
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