Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer

Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer

Oral microbiota have been implicated in pancreatic ductal adenocarcinoma (PDAC) and may contribute to chemotherapy resistance. While previous studies attributed bacteria-induced resistance to indirect host modulation, recent findings suggest a direct mechanism. <i>Escherichia coli</i> ex...

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Bibliographic Details
Main Authors: Geng Xu, Yaling Jiang, Chen Sun, Bernd W. Brandt, Kamran Nazmi, Luca Morelli, Giulia Lencioni, Elisa Giovannetti, Dongmei Deng
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
pancreatic cancer
gemcitabine
cytidine deaminase
HPLC
drug resistance
host microbial interactions
Online Access:https://www.mdpi.com/2218-273X/15/7/1018
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