MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

Abstract Diffuse large B-cell lymphoma (DLBCL) is an aggressive hematological malignancy with restricted effective therapy choices. Neither the recruitment of monocytes nor the functioning of the physiological mechanisms of macrophage polarization can be achieved without the involvement of the MCP-1...

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Bibliographic Details
Main Authors: Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Diffuse large B-cell lymphoma
MCP-1/CCR2 axis
M2 macrophages polarization
Progression
Antitumor immune response
Online Access:https://doi.org/10.1038/s41598-025-14527-6
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https://doi.org/10.1038/s41598-025-14527-6

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