Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance
Background and Aims: Chronic fatigue is common in patients with inflammatory bowel disease (IBD). The gut microbiota, specifically, microbial diversity and butyrate-producing bacteria have been linked to the fatigue pathogenesis. High-dose oral thiamine reduces fatigue, potentially through gut micro...
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Elsevier
2025-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572324001274 |
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| author | Sandra Bermúdez-Sánchez Palle Bager Jens Frederik Dahlerup Simon Mark Dahl Baunwall Tine Rask Licht Martin Steen Mortensen Christian Lodberg Hvas |
| author_facet | Sandra Bermúdez-Sánchez Palle Bager Jens Frederik Dahlerup Simon Mark Dahl Baunwall Tine Rask Licht Martin Steen Mortensen Christian Lodberg Hvas |
| author_sort | Sandra Bermúdez-Sánchez |
| collection | DOAJ |
| description | Background and Aims: Chronic fatigue is common in patients with inflammatory bowel disease (IBD). The gut microbiota, specifically, microbial diversity and butyrate-producing bacteria have been linked to the fatigue pathogenesis. High-dose oral thiamine reduces fatigue, potentially through gut microbiota modification. In this study, we investigated how the gut microbiota influences the efficacy of high-dose thiamine in alleviating chronic fatigue in quiescent IBD (qIBD). Methods: We analyzed the microbiota and short-chain fatty acids concentrations in fecal samples from patients with qIBD, with (n = 40) or without (n = 20) chronic fatigue. The 40 patients with qIBD and fatigue were included in a randomized, placebo-controlled, crossover trial to assess a 4-week high-oral-dose thiamine regimen. Results: Butyrate and butyrate-producing bacteria were similar in patients with and without fatigue and did not change with high-dose thiamine treatment. Notably, Faecalibacterium prausnitzii was more abundant in thiamine responders compared with nonresponders both pretreatment (P = .019) and post-treatment (P = .038). The relative abundances of Faecalibacterium prausnitzii and Roseburia hominis, both pretreatment and post-treatment, inversely correlated with IBD fatigue score changes for patients with chronic fatigue (PRE; R = −0.48, P = .004, and R = −0.40, P = .018; POST; R = −0.42, P = .012, and R = −0.40, P = .017) respectively. Conclusion: Faecalibacterium prausnitzii and Roseburia hominis may serve as markers for response to high-dose thiamine in alleviating chronic fatigue in patients with qIBD. The mechanistic role of gut bacteria and butyrate in patients with chronic fatigue and qIBD should be further explored. |
| format | Article |
| id | doaj-art-dd436b143e574af580c7d0afa79a88a7 |
| institution | Kabale University |
| issn | 2772-5723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj-art-dd436b143e574af580c7d0afa79a88a72025-01-18T05:05:31ZengElsevierGastro Hep Advances2772-57232025-01-0141100533Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii AbundanceSandra Bermúdez-Sánchez0Palle Bager1Jens Frederik Dahlerup2Simon Mark Dahl Baunwall3Tine Rask Licht4Martin Steen Mortensen5Christian Lodberg Hvas6National Food Institute, Technical University of Denmark, Kongens Lyngby, DenmarkDepartment of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Faculty of Health, Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Faculty of Health, Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Gastroenterology, Aarhus University Hospital, Aarhus, DenmarkNational Food Institute, Technical University of Denmark, Kongens Lyngby, DenmarkNational Food Institute, Technical University of Denmark, Kongens Lyngby, DenmarkDepartment of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Faculty of Health, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Correspondence: Address correspondence to: Christian Lodberg Hvas, MD, PhD, Department of Hepatology and Gastroenterology, Palle Juul-Jensens Boulevard 99, Aarhus 8200, Denmark.Background and Aims: Chronic fatigue is common in patients with inflammatory bowel disease (IBD). The gut microbiota, specifically, microbial diversity and butyrate-producing bacteria have been linked to the fatigue pathogenesis. High-dose oral thiamine reduces fatigue, potentially through gut microbiota modification. In this study, we investigated how the gut microbiota influences the efficacy of high-dose thiamine in alleviating chronic fatigue in quiescent IBD (qIBD). Methods: We analyzed the microbiota and short-chain fatty acids concentrations in fecal samples from patients with qIBD, with (n = 40) or without (n = 20) chronic fatigue. The 40 patients with qIBD and fatigue were included in a randomized, placebo-controlled, crossover trial to assess a 4-week high-oral-dose thiamine regimen. Results: Butyrate and butyrate-producing bacteria were similar in patients with and without fatigue and did not change with high-dose thiamine treatment. Notably, Faecalibacterium prausnitzii was more abundant in thiamine responders compared with nonresponders both pretreatment (P = .019) and post-treatment (P = .038). The relative abundances of Faecalibacterium prausnitzii and Roseburia hominis, both pretreatment and post-treatment, inversely correlated with IBD fatigue score changes for patients with chronic fatigue (PRE; R = −0.48, P = .004, and R = −0.40, P = .018; POST; R = −0.42, P = .012, and R = −0.40, P = .017) respectively. Conclusion: Faecalibacterium prausnitzii and Roseburia hominis may serve as markers for response to high-dose thiamine in alleviating chronic fatigue in patients with qIBD. The mechanistic role of gut bacteria and butyrate in patients with chronic fatigue and qIBD should be further explored.http://www.sciencedirect.com/science/article/pii/S2772572324001274Gut MicrobiotaChronic FatigueCrohn’s DiseaseColitisUlcerativeThiamine |
| spellingShingle | Sandra Bermúdez-Sánchez Palle Bager Jens Frederik Dahlerup Simon Mark Dahl Baunwall Tine Rask Licht Martin Steen Mortensen Christian Lodberg Hvas Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance Gastro Hep Advances Gut Microbiota Chronic Fatigue Crohn’s Disease Colitis Ulcerative Thiamine |
| title | Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance |
| title_full | Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance |
| title_fullStr | Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance |
| title_full_unstemmed | Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance |
| title_short | Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance |
| title_sort | thiamine reduced fatigue in quiescent inflammatory bowel disease is linked to faecalibacterium prausnitzii abundance |
| topic | Gut Microbiota Chronic Fatigue Crohn’s Disease Colitis Ulcerative Thiamine |
| url | http://www.sciencedirect.com/science/article/pii/S2772572324001274 |
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