Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study
Background Immune checkpoint inhibitor-associated acute kidney injury (ICI-AKI) is the most common renal complication and has attracted increasing amounts of attention. However, studies on this topic in Chinese cancer patients are very limited. Therefore, we conducted a retrospective study on the in...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2326186 |
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| author | Ping Zhou Bing Liu Ning Shen Xiaoting Fan Shangwei Lu Zhijuan Kong Ying Gao Zhimei Lv Rong Wang |
| author_facet | Ping Zhou Bing Liu Ning Shen Xiaoting Fan Shangwei Lu Zhijuan Kong Ying Gao Zhimei Lv Rong Wang |
| author_sort | Ping Zhou |
| collection | DOAJ |
| description | Background Immune checkpoint inhibitor-associated acute kidney injury (ICI-AKI) is the most common renal complication and has attracted increasing amounts of attention. However, studies on this topic in Chinese cancer patients are very limited. Therefore, we conducted a retrospective study on the incidence, risk factors, clinical features and renal recovery of ICI-AKI in all patients with malignancies treated with ICIs in Shandong Provincial Hospital Affiliated to Shandong First Medical University.Methods In this single-center retrospective cohort study, the data of 904 patients who received immune checkpoint inhibitors (ICIs) treatment were retrospectively analyzed. Multivariable logistic regression was used to identify the predictors of ICI-AKI.Results A total of 46 of 904 patients receiving ICIs developed ICI-AKI, and the incidence of ICI-AKI was 5.1%. Patients developed ICI-AKI at a median of 9 weeks (IQR 3–23) after ICIs initiation. A lower baseline estimated glomerular filtration rate (eGFR) and use of antibiotics were associated with a higher risk of ICI-AKI. Renal recovery occurred in 17 patients (46%) at a median of 4 weeks (IQR 2–8) after ICI-AKI, including 16 (43%) with complete recovery and 1 (3%) with partial recovery. Of the 14 rechallenged patients, only one developed recurrent ICI-AKI.Conclusions Patients with ICI-AKI were more likely to have impaired renal function at baseline and after treatment with antibiotics. Approximately half of the patients achieved renal recovery. |
| format | Article |
| id | doaj-art-dd4236719df04bf49189b973b43c3c0d |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-dd4236719df04bf49189b973b43c3c0d2025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2326186Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective studyPing Zhou0Bing Liu1Ning Shen2Xiaoting Fan3Shangwei Lu4Zhijuan Kong5Ying Gao6Zhimei Lv7Rong Wang8Department of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaBackground Immune checkpoint inhibitor-associated acute kidney injury (ICI-AKI) is the most common renal complication and has attracted increasing amounts of attention. However, studies on this topic in Chinese cancer patients are very limited. Therefore, we conducted a retrospective study on the incidence, risk factors, clinical features and renal recovery of ICI-AKI in all patients with malignancies treated with ICIs in Shandong Provincial Hospital Affiliated to Shandong First Medical University.Methods In this single-center retrospective cohort study, the data of 904 patients who received immune checkpoint inhibitors (ICIs) treatment were retrospectively analyzed. Multivariable logistic regression was used to identify the predictors of ICI-AKI.Results A total of 46 of 904 patients receiving ICIs developed ICI-AKI, and the incidence of ICI-AKI was 5.1%. Patients developed ICI-AKI at a median of 9 weeks (IQR 3–23) after ICIs initiation. A lower baseline estimated glomerular filtration rate (eGFR) and use of antibiotics were associated with a higher risk of ICI-AKI. Renal recovery occurred in 17 patients (46%) at a median of 4 weeks (IQR 2–8) after ICI-AKI, including 16 (43%) with complete recovery and 1 (3%) with partial recovery. Of the 14 rechallenged patients, only one developed recurrent ICI-AKI.Conclusions Patients with ICI-AKI were more likely to have impaired renal function at baseline and after treatment with antibiotics. Approximately half of the patients achieved renal recovery.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2326186Acute kidney injuryimmune checkpoint inhibitorsanti-PD-1 checkpoint inhibitorsimmunotherapyimmune-related adverse eventsmalignancies |
| spellingShingle | Ping Zhou Bing Liu Ning Shen Xiaoting Fan Shangwei Lu Zhijuan Kong Ying Gao Zhimei Lv Rong Wang Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study Renal Failure Acute kidney injury immune checkpoint inhibitors anti-PD-1 checkpoint inhibitors immunotherapy immune-related adverse events malignancies |
| title | Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study |
| title_full | Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study |
| title_fullStr | Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study |
| title_full_unstemmed | Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study |
| title_short | Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study |
| title_sort | acute kidney injury in patients treated with immune checkpoint inhibitors a single center retrospective study |
| topic | Acute kidney injury immune checkpoint inhibitors anti-PD-1 checkpoint inhibitors immunotherapy immune-related adverse events malignancies |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2326186 |
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