Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells
Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted pro...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3104727 |
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| _version_ | 1832560495025979392 |
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| author | Julio Aliberti |
| author_facet | Julio Aliberti |
| author_sort | Julio Aliberti |
| collection | DOAJ |
| description | Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. A potential result of unbalanced tolerogenic versus proinflammatory responses mediated by dendritic cells is associated with chronic inflammatory conditions, such as Crohn’s disease, ulcerative colitis, food allergies, and celiac disease. Herein, we review the dendritic cell population involved in mediating tolerance and immunity in mucosal surfaces, the progress in unveiling their development in vivo, and factors that can influence their functions. |
| format | Article |
| id | doaj-art-dd3e1f93d5e34930a8b8e4180a640ae8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dd3e1f93d5e34930a8b8e4180a640ae82025-02-03T01:27:31ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/31047273104727Immunity and Tolerance Induced by Intestinal Mucosal Dendritic CellsJulio Aliberti0Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. On the other hand, these cells must discriminate between commensal flora and invading pathogens and mount powerful immune response against pathogens. A potential result of unbalanced tolerogenic versus proinflammatory responses mediated by dendritic cells is associated with chronic inflammatory conditions, such as Crohn’s disease, ulcerative colitis, food allergies, and celiac disease. Herein, we review the dendritic cell population involved in mediating tolerance and immunity in mucosal surfaces, the progress in unveiling their development in vivo, and factors that can influence their functions.http://dx.doi.org/10.1155/2016/3104727 |
| spellingShingle | Julio Aliberti Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells Mediators of Inflammation |
| title | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
| title_full | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
| title_fullStr | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
| title_full_unstemmed | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
| title_short | Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells |
| title_sort | immunity and tolerance induced by intestinal mucosal dendritic cells |
| url | http://dx.doi.org/10.1155/2016/3104727 |
| work_keys_str_mv | AT julioaliberti immunityandtoleranceinducedbyintestinalmucosaldendriticcells |