Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications
<b>Background/Objectives:</b> Orthopedic implant infections are rare but represent a significant problem for patients, surgeons, and the healthcare systems. This is because these infections cause severe and persistent pain and, in some cases, may require revision of the implant, among ot...
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MDPI AG
2025-01-01
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| Series: | Antibiotics |
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| author | Harald Holeczek Michael de Wild Jasmine Ruegg Philipp Gruner Walter Moser Olivier Braissant |
| author_facet | Harald Holeczek Michael de Wild Jasmine Ruegg Philipp Gruner Walter Moser Olivier Braissant |
| author_sort | Harald Holeczek |
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| description | <b>Background/Objectives:</b> Orthopedic implant infections are rare but represent a significant problem for patients, surgeons, and the healthcare systems. This is because these infections cause severe and persistent pain and, in some cases, may require revision of the implant, among other things. Thus, there is strong interest in the use of antimicrobial coatings on orthopedic implants. Here, we investigate electrochemically deposited Ca(OH)<sub>2</sub> antimicrobial coating for its potential to be used on metallic orthopedic implants. <b>Methods:</b> A triphenyl tetrazolim chloride (TTC) assay and isothermal microcalorimetry (IMC) were used to determine the reduction in microbial activity on three sets of Ti parts (discs and screws): uncoated, coated with hydroxyapatite (HA), and coated with Ca(OH)<sub>2</sub>. <b>Results:</b> Using the TTC assay, a ~70% reduction in the growth of bacteria on Ca(OH)<sub>2</sub>-coated discs was found, and using IMC, bacterial growth on these discs showed a decreased rate and an increased lag phase up to 25 h. Each of these sets of results was statistically superior to the corresponding results obtained using the other sets of parts. <b>Conclusions:</b> The present results suggest that the Ca(OH)<sub>2</sub> coating may have potential for use on metallic orthopedic implants. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-dd2a85dceded409080703a5eead0a92a2025-01-24T13:18:57ZengMDPI AGAntibiotics2079-63822025-01-011419110.3390/antibiotics14010091Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant ApplicationsHarald Holeczek0Michael de Wild1Jasmine Ruegg2Philipp Gruner3Walter Moser4Olivier Braissant5Medicoat AG, Almuesenacherstrasse 2, 5506 Mägenwil, SwitzerlandFachhochschule Nordwestschweiz FHNW, Campus Muttenz, Hofackerstrasse 30, 4132 Muttenz, SwitzerlandFachhochschule Nordwestschweiz FHNW, Campus Muttenz, Hofackerstrasse 30, 4132 Muttenz, SwitzerlandMedicoat AG, Almuesenacherstrasse 2, 5506 Mägenwil, SwitzerlandAtesos Medical AG, Schachenallee 29, 5000 Aarau, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Hegenheimermattweg 167B/C, CH-4123 Allschwil, Switzerland<b>Background/Objectives:</b> Orthopedic implant infections are rare but represent a significant problem for patients, surgeons, and the healthcare systems. This is because these infections cause severe and persistent pain and, in some cases, may require revision of the implant, among other things. Thus, there is strong interest in the use of antimicrobial coatings on orthopedic implants. Here, we investigate electrochemically deposited Ca(OH)<sub>2</sub> antimicrobial coating for its potential to be used on metallic orthopedic implants. <b>Methods:</b> A triphenyl tetrazolim chloride (TTC) assay and isothermal microcalorimetry (IMC) were used to determine the reduction in microbial activity on three sets of Ti parts (discs and screws): uncoated, coated with hydroxyapatite (HA), and coated with Ca(OH)<sub>2</sub>. <b>Results:</b> Using the TTC assay, a ~70% reduction in the growth of bacteria on Ca(OH)<sub>2</sub>-coated discs was found, and using IMC, bacterial growth on these discs showed a decreased rate and an increased lag phase up to 25 h. Each of these sets of results was statistically superior to the corresponding results obtained using the other sets of parts. <b>Conclusions:</b> The present results suggest that the Ca(OH)<sub>2</sub> coating may have potential for use on metallic orthopedic implants.https://www.mdpi.com/2079-6382/14/1/91calcium dihydroxideCa(OH)<sub>2</sub>isothermal microcalorimetryantimicrobial surfacesorthopedic implantsorthopedic implant infections |
| spellingShingle | Harald Holeczek Michael de Wild Jasmine Ruegg Philipp Gruner Walter Moser Olivier Braissant Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications Antibiotics calcium dihydroxide Ca(OH)<sub>2</sub> isothermal microcalorimetry antimicrobial surfaces orthopedic implants orthopedic implant infections |
| title | Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications |
| title_full | Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications |
| title_fullStr | Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications |
| title_full_unstemmed | Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications |
| title_short | Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)<sub>2</sub>) Coating on Ti for Potential Metallic Orthopedic Implant Applications |
| title_sort | evaluation of antimicrobial performance of calcium dihydroxide ca oh sub 2 sub coating on ti for potential metallic orthopedic implant applications |
| topic | calcium dihydroxide Ca(OH)<sub>2</sub> isothermal microcalorimetry antimicrobial surfaces orthopedic implants orthopedic implant infections |
| url | https://www.mdpi.com/2079-6382/14/1/91 |
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