AMPK-Dependent Metabolic Regulation by PPAR Agonists
Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues suc...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/549101 |
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| _version_ | 1832545476283465728 |
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| author | Woo Hyung Lee Sang Geon Kim |
| author_facet | Woo Hyung Lee Sang Geon Kim |
| author_sort | Woo Hyung Lee |
| collection | DOAJ |
| description | Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels. It is noteworthy that PPARα or PPARγ agonists have pharmacological effects by modulating the activity of AMPK, which is a key cellular energy sensor. However, the role of AMPK in the metabolic effects of PPAR agonists has not been thoroughly focused. Moreover, AMPK activation by PPAR agonists seems to be independent of the receptor activation. This intriguing action of PPAR agonists may account in part for the mechanistic basis of the therapeutics in the treatment of metabolic disease. In this paper, the effects of PPAR agonists on metabolic functions were summarized with particular reference to their AMPK activity regulation. |
| format | Article |
| id | doaj-art-dd24093a87b749f5a207dcba6b3f4b68 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-dd24093a87b749f5a207dcba6b3f4b682025-02-03T07:25:46ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/549101549101AMPK-Dependent Metabolic Regulation by PPAR AgonistsWoo Hyung Lee0Sang Geon Kim1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of KoreaComprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels. It is noteworthy that PPARα or PPARγ agonists have pharmacological effects by modulating the activity of AMPK, which is a key cellular energy sensor. However, the role of AMPK in the metabolic effects of PPAR agonists has not been thoroughly focused. Moreover, AMPK activation by PPAR agonists seems to be independent of the receptor activation. This intriguing action of PPAR agonists may account in part for the mechanistic basis of the therapeutics in the treatment of metabolic disease. In this paper, the effects of PPAR agonists on metabolic functions were summarized with particular reference to their AMPK activity regulation.http://dx.doi.org/10.1155/2010/549101 |
| spellingShingle | Woo Hyung Lee Sang Geon Kim AMPK-Dependent Metabolic Regulation by PPAR Agonists PPAR Research |
| title | AMPK-Dependent Metabolic Regulation by PPAR Agonists |
| title_full | AMPK-Dependent Metabolic Regulation by PPAR Agonists |
| title_fullStr | AMPK-Dependent Metabolic Regulation by PPAR Agonists |
| title_full_unstemmed | AMPK-Dependent Metabolic Regulation by PPAR Agonists |
| title_short | AMPK-Dependent Metabolic Regulation by PPAR Agonists |
| title_sort | ampk dependent metabolic regulation by ppar agonists |
| url | http://dx.doi.org/10.1155/2010/549101 |
| work_keys_str_mv | AT woohyunglee ampkdependentmetabolicregulationbypparagonists AT sanggeonkim ampkdependentmetabolicregulationbypparagonists |