Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin
Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2013/314292 |
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| author | Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox |
| author_facet | Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox |
| author_sort | Yinka K. Davies |
| collection | DOAJ |
| description | Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin. |
| format | Article |
| id | doaj-art-dd1cf36ca4bb49db8357ff8da8a2466b |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-dd1cf36ca4bb49db8357ff8da8a2466b2025-02-03T01:22:55ZengWileyCase Reports in Transplantation2090-69432090-69512013-01-01201310.1155/2013/314292314292Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral VancomycinYinka K. Davies0Cynthia J. Tsay1Dario V. Caccamo2Kathleen M. Cox3Ricardo O. Castillo4Kenneth L. Cox5Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USAYale University, New Haven, CT 06510, USADepartment of Pathology, Sutter Medical Center, Sacramento, CA 95816, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USADivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 95762, USAPrimary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.http://dx.doi.org/10.1155/2013/314292 |
| spellingShingle | Yinka K. Davies Cynthia J. Tsay Dario V. Caccamo Kathleen M. Cox Ricardo O. Castillo Kenneth L. Cox Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin Case Reports in Transplantation |
| title | Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin |
| title_full | Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin |
| title_fullStr | Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin |
| title_full_unstemmed | Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin |
| title_short | Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin |
| title_sort | successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin |
| url | http://dx.doi.org/10.1155/2013/314292 |
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