Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro
The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/3521453 |
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| _version_ | 1832564575854133248 |
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| author | Dianhui Xiu Lin Liu Fengli Qiao Haishan Yang Lu Cui Guifeng Liu |
| author_facet | Dianhui Xiu Lin Liu Fengli Qiao Haishan Yang Lu Cui Guifeng Liu |
| author_sort | Dianhui Xiu |
| collection | DOAJ |
| description | The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro. Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells. In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3. |
| format | Article |
| id | doaj-art-dd1c22cfbbeb471fa2b65121c121a76c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-dd1c22cfbbeb471fa2b65121c121a76c2025-02-03T01:10:42ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/35214533521453Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In VitroDianhui Xiu0Lin Liu1Fengli Qiao2Haishan Yang3Lu Cui4Guifeng Liu5Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Ultrasonography, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaChina-Japan Union Hospital, Jilin University, Changchun 130033, ChinaDepartment of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, ChinaThe present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro. Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells. In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3.http://dx.doi.org/10.1155/2016/3521453 |
| spellingShingle | Dianhui Xiu Lin Liu Fengli Qiao Haishan Yang Lu Cui Guifeng Liu Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro Gastroenterology Research and Practice |
| title | Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro |
| title_full | Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro |
| title_fullStr | Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro |
| title_full_unstemmed | Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro |
| title_short | Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro |
| title_sort | annexin a2 coordinates stat3 to regulate the invasion and migration of colorectal cancer cells in vitro |
| url | http://dx.doi.org/10.1155/2016/3521453 |
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