Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats

Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats

Increased exposure to particulate matter (PM) from air pollution causes lung inflammation and increases morbidity and mortality due to respiratory diseases. Pirfenidone is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis. <b>Background/Objectives</b>: In this experiment...

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Bibliographic Details
Main Authors: Jun-Seok Sung, Il-Gyu Ko, Lakkyong Hwang, Sang-Hoon Kim, Jin Hee Han, Jung Won Jeon, Sae Rom Kim, Jeong Mi Lee, Cheon Woong Choi
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
particulate matter
pirfenidone
pulmonary fibrosis
inflammation
bronchoalveolar lavage fluid
Online Access:https://www.mdpi.com/2227-9059/13/4/989
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