Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases
Oxidative stress (OS) refers to the production of a substantial amount of reactive oxygen species (ROS), leading to cellular and organ damage. This imbalance between oxidant and antioxidant activity contributes to various diseases, including cancer, cardiovascular disease, diabetes, and neurodegener...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/70 |
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| author | Guangqi Guan Yaoxing Chen Yulan Dong |
| author_facet | Guangqi Guan Yaoxing Chen Yulan Dong |
| author_sort | Guangqi Guan |
| collection | DOAJ |
| description | Oxidative stress (OS) refers to the production of a substantial amount of reactive oxygen species (ROS), leading to cellular and organ damage. This imbalance between oxidant and antioxidant activity contributes to various diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative conditions. The body’s antioxidant system, mediated by various signaling pathways, includes the AMPK-SIRT1-FOXO pathway. In oxidative stress conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates the FOXO transcription factor. This cascade enhances mitochondrial function, reduces mitochondrial damage, and mitigates OS-induced cellular injury. This review provides a comprehensive analysis of the biological roles, regulatory mechanisms, and functions of the AMPK-SIRT1-FOXO pathway in diseases influenced by OS, offering new insights and methods for understanding OS pathogenesis and its therapeutic approaches. |
| format | Article |
| id | doaj-art-dcf3dac8f8b7468194ea5a23e9e6221a |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-dcf3dac8f8b7468194ea5a23e9e6221a2025-01-24T13:19:23ZengMDPI AGAntioxidants2076-39212025-01-011417010.3390/antiox14010070Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced DiseasesGuangqi Guan0Yaoxing Chen1Yulan Dong2College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaCollege of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaCollege of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaOxidative stress (OS) refers to the production of a substantial amount of reactive oxygen species (ROS), leading to cellular and organ damage. This imbalance between oxidant and antioxidant activity contributes to various diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative conditions. The body’s antioxidant system, mediated by various signaling pathways, includes the AMPK-SIRT1-FOXO pathway. In oxidative stress conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates the FOXO transcription factor. This cascade enhances mitochondrial function, reduces mitochondrial damage, and mitigates OS-induced cellular injury. This review provides a comprehensive analysis of the biological roles, regulatory mechanisms, and functions of the AMPK-SIRT1-FOXO pathway in diseases influenced by OS, offering new insights and methods for understanding OS pathogenesis and its therapeutic approaches.https://www.mdpi.com/2076-3921/14/1/70AMPK-SIRT1-FOXO pathwayoxidative stressreactive oxygen speciesantioxidant mechanism |
| spellingShingle | Guangqi Guan Yaoxing Chen Yulan Dong Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases Antioxidants AMPK-SIRT1-FOXO pathway oxidative stress reactive oxygen species antioxidant mechanism |
| title | Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases |
| title_full | Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases |
| title_fullStr | Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases |
| title_full_unstemmed | Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases |
| title_short | Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases |
| title_sort | unraveling the ampk sirt1 foxo pathway the in depth analysis and breakthrough prospects of oxidative stress induced diseases |
| topic | AMPK-SIRT1-FOXO pathway oxidative stress reactive oxygen species antioxidant mechanism |
| url | https://www.mdpi.com/2076-3921/14/1/70 |
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