A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth

A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth

Abstract Clade 2.3.4.4b H5N1 is causing an unprecedented outbreak in dairy cows in the United States. To understand if recent H5N1 viruses are changing their receptor use, we screened recombinant hemagglutinin (HA) from historical and recent 2.3.4.4b H5N1 viruses for binding to distinct glycans bear...

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Main Authors: Marina R. Good, Monica L. Fernández-Quintero, Wei Ji, Alesandra J. Rodriguez, Julianna Han, Andrew B. Ward, Jenna J. Guthmiller
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54934-3
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https://doi.org/10.1038/s41467-024-54934-3

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