CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity

CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity

Objectives: SF1 neurons of the ventromedial hypothalamus (VMH) play a pivotal role in regulating body weight and adiposity, particularly in response to a high-fat diet (HFD), as well as in the recovery from insulin-induced hypoglycemia. While the brain-specific CPT1C isoform is well known for its ro...

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Bibliographic Details
Main Authors: A. Fosch, D.S. Pizarro, S. Zagmutt, A.C. Reguera, G. Batallé, M. Rodríguez-García, J. García-Chica, O. Freire-Agulleiro, C. Miralpeix, P. Zizzari, D. Serra, L. Herrero, M. López, D. Cota, R. Rodríguez-Rodríguez, N. Casals
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
CPT1C
SF1 neurons
High-fat diet
Endocannabinoids
Adiposity
Food intake
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000626
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