Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men
Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were adm...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/2740372 |
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| author | Feng-fei Li Bing-li Liu Hong-hong Zhu Ting Li Wen-li Zhang Xiao-fei Su Jin-dan Wu Xue-qin Wang Ning Xu Wei-Nan Yu Qun Yuan Guan-cheng Qi Lei Ye Kok-Onn Lee Jian-hua Ma |
| author_facet | Feng-fei Li Bing-li Liu Hong-hong Zhu Ting Li Wen-li Zhang Xiao-fei Su Jin-dan Wu Xue-qin Wang Ning Xu Wei-Nan Yu Qun Yuan Guan-cheng Qi Lei Ye Kok-Onn Lee Jian-hua Ma |
| author_sort | Feng-fei Li |
| collection | DOAJ |
| description | Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. CGM was performed 2 times before and after completion of insulin treatment. Results. CGM data showed the expected significant improvement of mean amplitude glycemic excursion (MAGE) with CSII therapy. The older patients had lower hourly glucose concentrations from 0200 to 0700 o’clock compared to the younger patients at baseline. Surprisingly, in the older patient group, the male patients had a potential risk of hypoglycemia after CSII therapy, especially during periods from 2300 to 2400 and 0400 to 0600. Conclusions. Our data suggested that older male patients with newly diagnosed T2D may have lower nocturnal glucose concentrations. This may potentially increase the risk of nocturnal hypoglycemia during CSII therapy. This study was registered with Chinese Clinical Trial Registry, number CliCTR-TRC-11001218. |
| format | Article |
| id | doaj-art-dcc928ddd26c4fe8aeded7096e95be34 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dcc928ddd26c4fe8aeded7096e95be342025-02-03T06:11:38ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/27403722740372Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older MenFeng-fei Li0Bing-li Liu1Hong-hong Zhu2Ting Li3Wen-li Zhang4Xiao-fei Su5Jin-dan Wu6Xue-qin Wang7Ning Xu8Wei-Nan Yu9Qun Yuan10Guan-cheng Qi11Lei Ye12Kok-Onn Lee13Jian-hua Ma14Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First People’s Hospital of Nantong, Nantong, ChinaDepartment of Endocrinology, The First People’s Hospital of Lianyungang, Lianyungang, ChinaDepartment of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an, ChinaDepartment of Endocrinology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, ChinaDepartment of Endocrinology, Lianyungang Oriental Hospital, Lianyungang, ChinaNational Heart Research Institute Singapore, National Heart Centre Singapore, SingaporeDepartment of Medicine, National University of Singapore, SingaporeDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaObjectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. CGM was performed 2 times before and after completion of insulin treatment. Results. CGM data showed the expected significant improvement of mean amplitude glycemic excursion (MAGE) with CSII therapy. The older patients had lower hourly glucose concentrations from 0200 to 0700 o’clock compared to the younger patients at baseline. Surprisingly, in the older patient group, the male patients had a potential risk of hypoglycemia after CSII therapy, especially during periods from 2300 to 2400 and 0400 to 0600. Conclusions. Our data suggested that older male patients with newly diagnosed T2D may have lower nocturnal glucose concentrations. This may potentially increase the risk of nocturnal hypoglycemia during CSII therapy. This study was registered with Chinese Clinical Trial Registry, number CliCTR-TRC-11001218.http://dx.doi.org/10.1155/2017/2740372 |
| spellingShingle | Feng-fei Li Bing-li Liu Hong-hong Zhu Ting Li Wen-li Zhang Xiao-fei Su Jin-dan Wu Xue-qin Wang Ning Xu Wei-Nan Yu Qun Yuan Guan-cheng Qi Lei Ye Kok-Onn Lee Jian-hua Ma Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men Journal of Diabetes Research |
| title | Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men |
| title_full | Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men |
| title_fullStr | Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men |
| title_full_unstemmed | Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men |
| title_short | Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men |
| title_sort | continuous glucose monitoring in newly diagnosed type 2 diabetes patients reveals a potential risk of hypoglycemia in older men |
| url | http://dx.doi.org/10.1155/2017/2740372 |
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