Comparative Effects of Crocin and Losartan on RAGE, TGF‐β, TNF‐α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes

Comparative Effects of Crocin and Losartan on RAGE, TGF‐β, TNF‐α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes

ABSTRACT Background and Objectives AGEs, via RAGE, increase the development of hyperglycemia‐induced liver damage, and blocking this axis is associated with a reduction in liver disease progression. The goal of this study was to determine how crocin and losartan influenced RAGE, TNF‐α and TGF‐β gene...

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Main Authors: Shahnaz Rajabi, Yaser Mohammadi, Hamid Kabiri‐rad, Mahdiyeh Rajabi‐moghaddam, Azam Rezaei Farimani
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
crocin
diabetes
inflammatory markers
liver disease
losartan
Oxidative stress
Online Access:https://doi.org/10.1002/edm2.70016
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