NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions

NaNO2/HCl/TBAB Catalyst: A Controlled Aerobic Oxidation of Sulfide Substrate in the Preparation of Polmacoxib Intermediate Under Mild Conditions

The oxidation of sulfide substrate in one of the synthetic stages of Polmacoxib drug substance has been efficiently performed employing cost efficient NaNO2-HCl reagents in phase transfer catalyst TBAB containing biphasic MDC-Water reaction media at 0-5 °C temperature to afford sulfoxide intermedia...

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Bibliographic Details
Main Authors: Macchindra Kadam, Deepak Nale, Datta Thorat, Venkateswara Rao Vallu, Bollikonda Satyanarayana, Padi Pratap Reddy, Sayujjata R. Vaidya
Format: Article
Language:English
Published: Universidade Federal de Mato Grosso do Sul 2024-12-01
Series:Orbital: The Electronic Journal of Chemistry
Subjects:
NSAIDs
Oxidation
Pharmaceuticals
Phase transfer catalyst
Polmacoxib
Process chemistry
Online Access:https://periodicos.ufms.br/index.php/orbital/article/view/18740
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