Interorgan Crosstalk Contributing to β-Cell Dysfunction
Type 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance. In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and increasing β-cell mass. As the disease progresses, β-cel...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3605178 |
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| author | Katsuya Tanabe Kikuko Amo-Shiinoki Masayuki Hatanaka Yukio Tanizawa |
| author_facet | Katsuya Tanabe Kikuko Amo-Shiinoki Masayuki Hatanaka Yukio Tanizawa |
| author_sort | Katsuya Tanabe |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance. In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and increasing β-cell mass. As the disease progresses, β-cells fail to maintain these compensatory responses. This involves both extrinsic signals and mediators intrinsic to β-cells, which adversely affect β-cells by impairing insulin secretion, decreasing proliferative capacities, and ultimately causing apoptosis. In recent years, it has increasingly been recognized that changes in circulating levels of various factors from other organs play roles in β-cell dysfunction and cellular loss. In this review, we discuss current knowledge of interorgan communications underlying β-cell failure during the progression of T2DM. |
| format | Article |
| id | doaj-art-dc5af6378e0e402b9267513e287d177c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dc5af6378e0e402b9267513e287d177c2025-02-03T06:11:41ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/36051783605178Interorgan Crosstalk Contributing to β-Cell DysfunctionKatsuya Tanabe0Kikuko Amo-Shiinoki1Masayuki Hatanaka2Yukio Tanizawa3Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JapanType 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance. In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and increasing β-cell mass. As the disease progresses, β-cells fail to maintain these compensatory responses. This involves both extrinsic signals and mediators intrinsic to β-cells, which adversely affect β-cells by impairing insulin secretion, decreasing proliferative capacities, and ultimately causing apoptosis. In recent years, it has increasingly been recognized that changes in circulating levels of various factors from other organs play roles in β-cell dysfunction and cellular loss. In this review, we discuss current knowledge of interorgan communications underlying β-cell failure during the progression of T2DM.http://dx.doi.org/10.1155/2017/3605178 |
| spellingShingle | Katsuya Tanabe Kikuko Amo-Shiinoki Masayuki Hatanaka Yukio Tanizawa Interorgan Crosstalk Contributing to β-Cell Dysfunction Journal of Diabetes Research |
| title | Interorgan Crosstalk Contributing to β-Cell Dysfunction |
| title_full | Interorgan Crosstalk Contributing to β-Cell Dysfunction |
| title_fullStr | Interorgan Crosstalk Contributing to β-Cell Dysfunction |
| title_full_unstemmed | Interorgan Crosstalk Contributing to β-Cell Dysfunction |
| title_short | Interorgan Crosstalk Contributing to β-Cell Dysfunction |
| title_sort | interorgan crosstalk contributing to β cell dysfunction |
| url | http://dx.doi.org/10.1155/2017/3605178 |
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