20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1

20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1

Currently, intensive chemotherapy with cytarabine and anthracycline (the “7 + 3” regimen) and hypomethylating agents remains the standard treatment for patients with acute myeloid leukemia (AML). Despite advances in treatment such as targeted therapies, patient outcomes remain unsatisfactory due to...

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Bibliographic Details
Main Authors: Meng Xu, Feng Hao, Shuangshuang Wu, Zhanning Qu, Junying Li, Shuang Chen, Fang Fang, Yundong Zhao, Cheng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
acute myeloid leukemia
20(S)-protopanaxadiol
MCL-1
Bcl-XL
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530270/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1530270/full

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