X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation

X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation

Abstract Background Studies have indicated that X-linked microRNAs (miRNAs) play a role in the pathogenesis of rheumatoid arthritis (RA) and its gender-specific differences. However, research on specific miRNAs remains limited. This study aims to investigate the possible role of X-linked miR-542-5p...

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Main Authors: Jiu Jie Yang, Zhi Li, Lin Na Wang, Bai Xiong Huang, Jerome P. L. Ng, Xiong Fei Xu, Yu Ping Wang, David Wei Zhang, Bo Qin, Ding Qi Zhang, Chang Liu, Wei Dan Luo, Betty Yuen Kwan Law, Hui Miao Wang, Meng Han Liu, Xiao Yun Yun, Joyce Tsz Wai Chan, Wan Yu Wu, Yi Ting Li, Peter Kam Fai Cheung, Man Chon Pou, Kat Sang Ha, Wang Fai Ao Ieong, Chi Hou Leong, Kit Ieng Leong, Chan Wang Lei, Lek Hang Cheang, Vincent Kam Wai Wong
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biomarker Research
Subjects:
Rheumatoid arthritis (RA)
Sex disparity
Autoimmune disease
X chromosome
X-linked microRNA
Online Access:https://doi.org/10.1186/s40364-025-00741-x
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https://doi.org/10.1186/s40364-025-00741-x

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