Synthesis, Biological Evaluation, Molecular Dynamics, and QM-MM Calculation of Spiro-Acridine Derivatives Against Leishmaniasis

Synthesis, Biological Evaluation, Molecular Dynamics, and QM-MM Calculation of Spiro-Acridine Derivatives Against Leishmaniasis

Leishmaniasis is a neglected tropical disease caused by <i>Leishmania</i> sp. The therapeutic arsenal is reduced and limited. In this context, acridine derivatives present themselves as promising leishmanicidal compounds. This paper involved synthesizing and evaluating the antileishmania...

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Bibliographic Details
Main Authors: Sonaly Albino, Michelangela Nobre, Jamire da Silva, Malu dos Reis, Maria Nascimento, Mayara de Oliveira, Tatiana Borges, Lucas Albuquerque, Selma Kuckelhaus, Luis Alves, Fábio dos Santos, Maria de Lima, Igor Nascimento, Teresinha da Silva, Ricardo de Moura
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
spontaneous cyclization
molecular simplification
leishmaniasis
immunomodulation
structure–activity relationship
QM-MM
Online Access:https://www.mdpi.com/2076-2607/13/6/1297
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