Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes
Background and Aims. Vinegar has been shown to have a glucose-lowering effect in patients with glucose abnormalities. However, the mechanisms of this effect are still obscure. The aim of this randomised, crossover study was to investigate the effect of vinegar on glucose metabolism in muscle which...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/175204 |
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| author | Panayota Mitrou Eleni Petsiou Emilia Papakonstantinou Eirini Maratou Vaia Lambadiari Panayiotis Dimitriadis Filio Spanoudi Sotirios A. Raptis George Dimitriadis |
| author_facet | Panayota Mitrou Eleni Petsiou Emilia Papakonstantinou Eirini Maratou Vaia Lambadiari Panayiotis Dimitriadis Filio Spanoudi Sotirios A. Raptis George Dimitriadis |
| author_sort | Panayota Mitrou |
| collection | DOAJ |
| description | Background and Aims. Vinegar has been shown to have a glucose-lowering effect in patients with glucose abnormalities. However, the mechanisms of this effect are still obscure. The aim of this randomised, crossover study was to investigate the effect of vinegar on glucose metabolism in muscle which is the most important tissue for insulin-stimulated glucose disposal. Materials and Methods. Eleven subjects with DM2 consumed vinegar or placebo (at random order on two separate days, a week apart), before a mixed meal. Plasma glucose, insulin, triglycerides, nonesterified fatty acids (NEFA), and glycerol were measured preprandially and at 30–60 min for 300 min postprandially from the radial artery and from a forearm vein. Muscle blood flow was measured with strain-gauge plethysmography. Glucose uptake was calculated as the arteriovenous difference of glucose multiplied by blood flow. Results. Vinegar compared to placebo (1) increased forearm glucose uptake (p=0.0357), (2) decreased plasma glucose (p=0.0279), insulin (p=0.0457), and triglycerides (p=0.0439), and (3) did not change NEFA and glycerol. Conclusions. In DM2 vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar’s effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle. This trial is registered with Clinicaltrials.gov NCT02309424. |
| format | Article |
| id | doaj-art-dc385e74e3414d8f93c67fbd8217b1ae |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-dc385e74e3414d8f93c67fbd8217b1ae2025-02-03T01:24:14ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/175204175204Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 DiabetesPanayota Mitrou0Eleni Petsiou1Emilia Papakonstantinou2Eirini Maratou3Vaia Lambadiari4Panayiotis Dimitriadis5Filio Spanoudi6Sotirios A. Raptis7George Dimitriadis8Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, GreeceHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, GreeceDepartment of Water Resources and Environmental Engineering, School of Civil Engineering, NTUA, Heroon Polytechniou 5-9, 15780 Athens, Greece2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, GreeceHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, GreeceBackground and Aims. Vinegar has been shown to have a glucose-lowering effect in patients with glucose abnormalities. However, the mechanisms of this effect are still obscure. The aim of this randomised, crossover study was to investigate the effect of vinegar on glucose metabolism in muscle which is the most important tissue for insulin-stimulated glucose disposal. Materials and Methods. Eleven subjects with DM2 consumed vinegar or placebo (at random order on two separate days, a week apart), before a mixed meal. Plasma glucose, insulin, triglycerides, nonesterified fatty acids (NEFA), and glycerol were measured preprandially and at 30–60 min for 300 min postprandially from the radial artery and from a forearm vein. Muscle blood flow was measured with strain-gauge plethysmography. Glucose uptake was calculated as the arteriovenous difference of glucose multiplied by blood flow. Results. Vinegar compared to placebo (1) increased forearm glucose uptake (p=0.0357), (2) decreased plasma glucose (p=0.0279), insulin (p=0.0457), and triglycerides (p=0.0439), and (3) did not change NEFA and glycerol. Conclusions. In DM2 vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar’s effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle. This trial is registered with Clinicaltrials.gov NCT02309424.http://dx.doi.org/10.1155/2015/175204 |
| spellingShingle | Panayota Mitrou Eleni Petsiou Emilia Papakonstantinou Eirini Maratou Vaia Lambadiari Panayiotis Dimitriadis Filio Spanoudi Sotirios A. Raptis George Dimitriadis Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes Journal of Diabetes Research |
| title | Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes |
| title_full | Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes |
| title_fullStr | Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes |
| title_full_unstemmed | Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes |
| title_short | Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes |
| title_sort | vinegar consumption increases insulin stimulated glucose uptake by the forearm muscle in humans with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2015/175204 |
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