Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease
Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approve...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/9358153 |
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| author | Gerson Suarez-Cedeno Jessika Suescun Mya C. Schiess |
| author_facet | Gerson Suarez-Cedeno Jessika Suescun Mya C. Schiess |
| author_sort | Gerson Suarez-Cedeno |
| collection | DOAJ |
| description | Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson’s disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy. In 2013 the EARLY-STIM trial provided Class I evidence for the use of DBS earlier in Parkinson’s disease. This finding led to the most recent FDA approval in patients with at least 4 years of disease duration and 4 months of motor complications as an adjunct therapy for patients not adequately controlled with medications. This following review highlights the historical development and advances made overtime in DBS implantation, the current application, and the challenges that come with it. |
| format | Article |
| id | doaj-art-dc07fa5ca08e41c18316040c5a331e07 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-dc07fa5ca08e41c18316040c5a331e072025-02-03T01:30:58ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/93581539358153Earlier Intervention with Deep Brain Stimulation for Parkinson’s DiseaseGerson Suarez-Cedeno0Jessika Suescun1Mya C. Schiess2Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USADepartment of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USADepartment of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USANeuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson’s disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy. In 2013 the EARLY-STIM trial provided Class I evidence for the use of DBS earlier in Parkinson’s disease. This finding led to the most recent FDA approval in patients with at least 4 years of disease duration and 4 months of motor complications as an adjunct therapy for patients not adequately controlled with medications. This following review highlights the historical development and advances made overtime in DBS implantation, the current application, and the challenges that come with it.http://dx.doi.org/10.1155/2017/9358153 |
| spellingShingle | Gerson Suarez-Cedeno Jessika Suescun Mya C. Schiess Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease Parkinson's Disease |
| title | Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease |
| title_full | Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease |
| title_fullStr | Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease |
| title_full_unstemmed | Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease |
| title_short | Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease |
| title_sort | earlier intervention with deep brain stimulation for parkinson s disease |
| url | http://dx.doi.org/10.1155/2017/9358153 |
| work_keys_str_mv | AT gersonsuarezcedeno earlierinterventionwithdeepbrainstimulationforparkinsonsdisease AT jessikasuescun earlierinterventionwithdeepbrainstimulationforparkinsonsdisease AT myacschiess earlierinterventionwithdeepbrainstimulationforparkinsonsdisease |