Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett’s esophagus

Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett’s esophagus

Bile acids are a major component of gastro-esophageal refluxate, thought to contribute to the development of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). As the microbiome shifts with EAC progression and bile acids influence bacterial composition, we examined these connections in a...

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Bibliographic Details
Main Authors: Ceylan Tanes, Yun Li, Gary W. Falk, Gregory G. Ginsberg, Kenneth K. Wang, Prasad G. Iyer, Charles J. Lightdale, Armando Del Portillo, Stephen M. Lagana, Timothy C. Wang, Anil K. Rustgi, Michael Quante, Zhezhen Jin, Gary D. Wu, Elliot S. Friedman, Kyle Bittinger, Hongzhe Li, Julian A. Abrams
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Barrett’s esophagus
esophageal adenocarcinoma
bile acids
microbiome
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2545420
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