Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery
The present study aimed to develop and optimize a nanoemulsifying preconcentrate formulation of curcumin with good emulsification ability and optimal globule size, for controlled targeting in colon. Content of formulation variables, namely, X1 (Peceol), X2 (Cremophor-EL), and X3 (Transcutol HP), wer...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/541510 |
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| author | Jyoti Wadhwa Abhay Asthana Gyati Shilakari Arun Kumar Chopra Ranjit Singh |
| author_facet | Jyoti Wadhwa Abhay Asthana Gyati Shilakari Arun Kumar Chopra Ranjit Singh |
| author_sort | Jyoti Wadhwa |
| collection | DOAJ |
| description | The present study aimed to develop and optimize a nanoemulsifying preconcentrate formulation of curcumin with good emulsification ability and optimal globule size, for controlled targeting in colon. Content of formulation variables, namely, X1 (Peceol), X2 (Cremophor-EL), and X3 (Transcutol HP), were optimized by Box-Behnken design of experiments for its impact on mean globule size (Y1), emulsification time (Y2), and time required for drug release (85%) in phosphate buffer (pH 7.2), t85% (Y3). Transmission electron micrographs confirmed that there is no coalescence among globules, with size range concordant with the globule size analysis by dynamic light scattering technique (100 nm). 3D plots indicated that concentration of formulation ingredients significantly influences the formulation properties (globule size, emulsification time, and drug release). In vitro release profile (in phosphate buffer; pH 7.2) represents the fact that more than 50% of the drug was released within initial 15 min whereas in vivo release showed limited systemic absorption (Cmax 200 ng/mL) of curcumin. Stability study ensures the protection of drug in alkaline media which may further confirm the localised delivery of drug to colonic region. Study demonstrated that the nanoemulsifying preconcentrate can be a promising system for the colon specific delivery of curcumin to treat local pathologies. |
| format | Article |
| id | doaj-art-dbeb518c61a345da812d5a66dae2fcc9 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dbeb518c61a345da812d5a66dae2fcc92025-02-03T01:30:45ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/541510541510Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon DeliveryJyoti Wadhwa0Abhay Asthana1Gyati Shilakari2Arun Kumar Chopra3Ranjit Singh4M. M. College of Pharmacy, M. M. University, Mullana, Ambala 133207, IndiaM. M. College of Pharmacy, M. M. University, Mullana, Ambala 133207, IndiaM. M. College of Pharmacy, M. M. University, Mullana, Ambala 133207, IndiaInternational Institute of Pharmaceutical Sciences, Jhundpur, Sonepat 131023, IndiaGovernment College of Pharmacy, Rohru, Shimla 171207, IndiaThe present study aimed to develop and optimize a nanoemulsifying preconcentrate formulation of curcumin with good emulsification ability and optimal globule size, for controlled targeting in colon. Content of formulation variables, namely, X1 (Peceol), X2 (Cremophor-EL), and X3 (Transcutol HP), were optimized by Box-Behnken design of experiments for its impact on mean globule size (Y1), emulsification time (Y2), and time required for drug release (85%) in phosphate buffer (pH 7.2), t85% (Y3). Transmission electron micrographs confirmed that there is no coalescence among globules, with size range concordant with the globule size analysis by dynamic light scattering technique (100 nm). 3D plots indicated that concentration of formulation ingredients significantly influences the formulation properties (globule size, emulsification time, and drug release). In vitro release profile (in phosphate buffer; pH 7.2) represents the fact that more than 50% of the drug was released within initial 15 min whereas in vivo release showed limited systemic absorption (Cmax 200 ng/mL) of curcumin. Stability study ensures the protection of drug in alkaline media which may further confirm the localised delivery of drug to colonic region. Study demonstrated that the nanoemulsifying preconcentrate can be a promising system for the colon specific delivery of curcumin to treat local pathologies.http://dx.doi.org/10.1155/2015/541510 |
| spellingShingle | Jyoti Wadhwa Abhay Asthana Gyati Shilakari Arun Kumar Chopra Ranjit Singh Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery The Scientific World Journal |
| title | Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery |
| title_full | Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery |
| title_fullStr | Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery |
| title_full_unstemmed | Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery |
| title_short | Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery |
| title_sort | development and evaluation of nanoemulsifying preconcentrate of curcumin for colon delivery |
| url | http://dx.doi.org/10.1155/2015/541510 |
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