Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review
Abstract Background The present systematic review intended to evaluate the current evidence on the modalities used for treating iatrogenic late paresthesia in the oral tissues innervated by the mandibular branch of the trigeminal nerve. Main text As a common side effect of dental procedures, paresth...
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SpringerOpen
2024-07-01
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| Series: | Maxillofacial Plastic and Reconstructive Surgery |
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| Online Access: | https://doi.org/10.1186/s40902-024-00438-5 |
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| author | Elham Keykha Elahe Tahmasebi Mahdi Hadilou |
| author_facet | Elham Keykha Elahe Tahmasebi Mahdi Hadilou |
| author_sort | Elham Keykha |
| collection | DOAJ |
| description | Abstract Background The present systematic review intended to evaluate the current evidence on the modalities used for treating iatrogenic late paresthesia in the oral tissues innervated by the mandibular branch of the trigeminal nerve. Main text As a common side effect of dental procedures, paresthesia can exert a profound adverse effect on patients’ quality of life. The inferior alveolar nerve (IAN) and lingual nerve (LN) have the highest chance of injury during several dental procedures, including mandibular orthognathic surgeries, implant placement, extraction of the third molar, anesthetic injections, flap elevation, and endodontic treatments. Moreover, several methods have been proposed for treating iatrogenic late paresthesia, including photobiomodulation (PBM), microsurgery, medication, and close observation until achieving spontaneous recovery of sensation. However, no gold standard treatment for iatrogenic paresthesia has been agreed upon up to now. The present study included a comprehensive search of the databases of PubMed, Embase, Scopus, and Web of Science up to December 04, 2023, resulting in a total of 3122 related studies. Then, the titles, abstracts, and full texts of the studies were evaluated. Ultimately, seven controlled randomized trials (RCTs) were included in the final analysis. Also, the risk of bias was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. Among all fields, randomization, allocation concealment, and data analysis were found to have the highest chance of bias in the included studies. Conclusions In conclusion, PBM, vitamin B12, and corticosteroids could accelerate the recovery of late paresthesia. However, considering the low sample size of the included studies and the high risk of methodological bias, it is recommended to perform further RCTs with robust study designs following Good Clinical Practice (GCP) guidelines to achieve more reliable results. |
| format | Article |
| id | doaj-art-dbe9733f139a4139b8a53bce5926d08f |
| institution | Kabale University |
| issn | 2288-8586 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Maxillofacial Plastic and Reconstructive Surgery |
| spelling | doaj-art-dbe9733f139a4139b8a53bce5926d08f2025-01-19T12:13:59ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862024-07-0146111110.1186/s40902-024-00438-5Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic reviewElham Keykha0Elahe Tahmasebi1Mahdi Hadilou2Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical SciencesResearch Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical SciencesResearch Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical SciencesAbstract Background The present systematic review intended to evaluate the current evidence on the modalities used for treating iatrogenic late paresthesia in the oral tissues innervated by the mandibular branch of the trigeminal nerve. Main text As a common side effect of dental procedures, paresthesia can exert a profound adverse effect on patients’ quality of life. The inferior alveolar nerve (IAN) and lingual nerve (LN) have the highest chance of injury during several dental procedures, including mandibular orthognathic surgeries, implant placement, extraction of the third molar, anesthetic injections, flap elevation, and endodontic treatments. Moreover, several methods have been proposed for treating iatrogenic late paresthesia, including photobiomodulation (PBM), microsurgery, medication, and close observation until achieving spontaneous recovery of sensation. However, no gold standard treatment for iatrogenic paresthesia has been agreed upon up to now. The present study included a comprehensive search of the databases of PubMed, Embase, Scopus, and Web of Science up to December 04, 2023, resulting in a total of 3122 related studies. Then, the titles, abstracts, and full texts of the studies were evaluated. Ultimately, seven controlled randomized trials (RCTs) were included in the final analysis. Also, the risk of bias was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. Among all fields, randomization, allocation concealment, and data analysis were found to have the highest chance of bias in the included studies. Conclusions In conclusion, PBM, vitamin B12, and corticosteroids could accelerate the recovery of late paresthesia. However, considering the low sample size of the included studies and the high risk of methodological bias, it is recommended to perform further RCTs with robust study designs following Good Clinical Practice (GCP) guidelines to achieve more reliable results.https://doi.org/10.1186/s40902-024-00438-5Mandibular nerve injuriesParesthesiaSystematic reviewTrigeminal nerve injuries |
| spellingShingle | Elham Keykha Elahe Tahmasebi Mahdi Hadilou Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review Maxillofacial Plastic and Reconstructive Surgery Mandibular nerve injuries Paresthesia Systematic review Trigeminal nerve injuries |
| title | Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review |
| title_full | Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review |
| title_fullStr | Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review |
| title_full_unstemmed | Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review |
| title_short | Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review |
| title_sort | therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve a systematic review |
| topic | Mandibular nerve injuries Paresthesia Systematic review Trigeminal nerve injuries |
| url | https://doi.org/10.1186/s40902-024-00438-5 |
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