Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices
Theta oscillations over the posterior medial frontal cortex (pMFC) and lateral prefrontal cortex (LPFC) play vital roles in sustained attention. Specifically, pMFC power and pMFC-LPFC synchronization correlate with cognitive control in sustained-attention-related tasks, but the causal relationships...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/5573471 |
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| author | Jinwen Wei Zhiguo Zhang Ziqing Yao Dong Ming Peng Zhou |
| author_facet | Jinwen Wei Zhiguo Zhang Ziqing Yao Dong Ming Peng Zhou |
| author_sort | Jinwen Wei |
| collection | DOAJ |
| description | Theta oscillations over the posterior medial frontal cortex (pMFC) and lateral prefrontal cortex (LPFC) play vital roles in sustained attention. Specifically, pMFC power and pMFC-LPFC synchronization correlate with cognitive control in sustained-attention-related tasks, but the causal relationships remain unknown. In the present study, we first analyzed the correlation between EEG theta oscillations (characterized by time-frequency power and phase-based connectivity) and the level of sustained attention (Experiment 1) and then utilized transcranial alternating current stimulation (tACS) to modulate theta oscillations and in turn observed its effects on sustained attention (Experiment 2). In Experiment 1, two time-frequency regions of interest (ROIs) were determined, in which high/low time-frequency power and high/low phase-based connectivity corresponded to high/low-level sustained attention. In Experiment 2, time-frequency power and phase-based connectivity of theta oscillations were compared between the sham and tACS groups within the time-frequency ROIs determined in Experiment 1. Results showed that phase-based connectivity between pMFC and LPFC significantly decreased in the tACS group compared with the sham group during the first five minutes of the poststimulation period. Moreover, a marginal trend existed that sustained attention was downregulated by tACS in the same time interval, suggesting that theta phase synchronization between pMFC and LPFC may play a causal role in sustained attention. |
| format | Article |
| id | doaj-art-dbdf5e3e773d4f2d9dd6aa5afe161cba |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-dbdf5e3e773d4f2d9dd6aa5afe161cba2025-02-03T05:47:08ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/55734715573471Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal CorticesJinwen Wei0Zhiguo Zhang1Ziqing Yao2Dong Ming3Peng Zhou4School of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, ChinaDepartment of Psychology, The University of Hong Kong, Hong Kong S.A.R., ChinaSchool of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaSchool of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, ChinaTheta oscillations over the posterior medial frontal cortex (pMFC) and lateral prefrontal cortex (LPFC) play vital roles in sustained attention. Specifically, pMFC power and pMFC-LPFC synchronization correlate with cognitive control in sustained-attention-related tasks, but the causal relationships remain unknown. In the present study, we first analyzed the correlation between EEG theta oscillations (characterized by time-frequency power and phase-based connectivity) and the level of sustained attention (Experiment 1) and then utilized transcranial alternating current stimulation (tACS) to modulate theta oscillations and in turn observed its effects on sustained attention (Experiment 2). In Experiment 1, two time-frequency regions of interest (ROIs) were determined, in which high/low time-frequency power and high/low phase-based connectivity corresponded to high/low-level sustained attention. In Experiment 2, time-frequency power and phase-based connectivity of theta oscillations were compared between the sham and tACS groups within the time-frequency ROIs determined in Experiment 1. Results showed that phase-based connectivity between pMFC and LPFC significantly decreased in the tACS group compared with the sham group during the first five minutes of the poststimulation period. Moreover, a marginal trend existed that sustained attention was downregulated by tACS in the same time interval, suggesting that theta phase synchronization between pMFC and LPFC may play a causal role in sustained attention.http://dx.doi.org/10.1155/2021/5573471 |
| spellingShingle | Jinwen Wei Zhiguo Zhang Ziqing Yao Dong Ming Peng Zhou Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices Neural Plasticity |
| title | Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices |
| title_full | Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices |
| title_fullStr | Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices |
| title_full_unstemmed | Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices |
| title_short | Modulation of Sustained Attention by Theta-tACS over the Lateral and Medial Frontal Cortices |
| title_sort | modulation of sustained attention by theta tacs over the lateral and medial frontal cortices |
| url | http://dx.doi.org/10.1155/2021/5573471 |
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