Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models
Background: Gestational pesticide exposure may negatively affect newborn outcomes. Prior results evaluating nonpersistent pesticides are inconsistent. Objective: To examine associations between gestational exposure to nonpersistent pesticides and newborn outcomes and identify critical windows of sus...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025000431 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557605446221824 |
|---|---|
| author | Wylie BJ Kaali S Duttweiler L Ae-Ngibise KA Mujtaba M Tawiah C Gibson E Calafat AM Ospina M Jack DJ Agyei O Lee AG Roberts DJ Boamah-Kaali EA Factor-Litvak P Modest AM Hauser R Coull BA Asante KP |
| author_facet | Wylie BJ Kaali S Duttweiler L Ae-Ngibise KA Mujtaba M Tawiah C Gibson E Calafat AM Ospina M Jack DJ Agyei O Lee AG Roberts DJ Boamah-Kaali EA Factor-Litvak P Modest AM Hauser R Coull BA Asante KP |
| author_sort | Wylie BJ |
| collection | DOAJ |
| description | Background: Gestational pesticide exposure may negatively affect newborn outcomes. Prior results evaluating nonpersistent pesticides are inconsistent. Objective: To examine associations between gestational exposure to nonpersistent pesticides and newborn outcomes and identify critical windows of susceptibility. Study Design: In a Ghanaian pregnancy cohort, we measured select biomarkers of organophosphate, pyrethroid, and herbicide pesticides in repeated urine samples (1–5/participant). We developed a new model for assessing critical windows of vulnerability from irregularly-timed measurements of nonpersistent pesticides, leveraging strengths from multiple informant and distributed lag models. We estimated associations of biomarker concentrations with newborn anthropometrics and gestational length, adjusting for confounders and exploring effect modification by infant sex and placental malaria. Results: 1,211 pregnant women contributed 3,786 gestational urinary samples. In models assuming constant associations with exposures across pregnancy, in a given week a doubling of 3-phenoxybenzoic acid (pyrethroid biomarker) was associated with a −15.8 g difference in birth weight (95 % CI:-28.1,-3.6), and a doubling of the 2,4-dichlorophenoxyacetic acid (2,4-D, herbicide biomarker) was associated with an 11.1 g increase in birth weight (95 % CI:1.0,21.1). In time-varying models, significant associations were identified for pyrethroid exposure measured between weeks 16–27, and for 2,4-D exposure measured during weeks 25–33. Organophosphates were not associated with birth weight. No associations were found for birth length or head circumference for any pesticide. In constant association models, a doubling of weekly 2,4-D was associated with a 0.05 week increase in gestational length (95 %CI:0.01,0.09); no associations were found with other biomarkers. Conclusions: We identified associations between gestational exposure to nonpersistent pesticides and both birth size and gestational length. Extending multiple informant models to account for the complex data structure allowed us to discern effects in opposing directions by distinct pesticide classes. While estimated effects for a given week were modest, prolonged or repeated exposures could result in larger cumulative impacts. |
| format | Article |
| id | doaj-art-dbde39114f804c4fb39c8c9ce77b0922 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-dbde39114f804c4fb39c8c9ce77b09222025-02-03T04:16:28ZengElsevierEnvironment International0160-41202025-02-01196109292Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant modelsWylie BJ0Kaali S1Duttweiler L2Ae-Ngibise KA3Mujtaba M4Tawiah C5Gibson E6Calafat AM7Ospina M8Jack DJ9Agyei O10Lee AG11Roberts DJ12Boamah-Kaali EA13Factor-Litvak P14Modest AM15Hauser R16Coull BA17Asante KP18Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, United States; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 West. 168th Street, New York, NY 10032, United States; Corresponding author.Kintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United StatesKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United StatesDivision of Laboratory Sciences, Centers for Disease Control and Prevention, 3719 N. Peachtree Road, Atlanta, GA 30341, United StatesDivision of Laboratory Sciences, Centers for Disease Control and Prevention, 3719 N. Peachtree Road, Atlanta, GA 30341, United StatesDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 West. 168th Street, New York, NY 10032, United StatesKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, United StatesDepartment of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United StatesKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaDepartment of Epidemiology, Columbia University Mailman School of Public Health, 722 West. 168th Street, New York, NY 10032, United StatesDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United StatesDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United StatesDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United States; Department of Environmental Health, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, United StatesKintampo Health Research Centre, Ghana Health Service, P.O. Box 200, Kintampo North Municipality, GhanaBackground: Gestational pesticide exposure may negatively affect newborn outcomes. Prior results evaluating nonpersistent pesticides are inconsistent. Objective: To examine associations between gestational exposure to nonpersistent pesticides and newborn outcomes and identify critical windows of susceptibility. Study Design: In a Ghanaian pregnancy cohort, we measured select biomarkers of organophosphate, pyrethroid, and herbicide pesticides in repeated urine samples (1–5/participant). We developed a new model for assessing critical windows of vulnerability from irregularly-timed measurements of nonpersistent pesticides, leveraging strengths from multiple informant and distributed lag models. We estimated associations of biomarker concentrations with newborn anthropometrics and gestational length, adjusting for confounders and exploring effect modification by infant sex and placental malaria. Results: 1,211 pregnant women contributed 3,786 gestational urinary samples. In models assuming constant associations with exposures across pregnancy, in a given week a doubling of 3-phenoxybenzoic acid (pyrethroid biomarker) was associated with a −15.8 g difference in birth weight (95 % CI:-28.1,-3.6), and a doubling of the 2,4-dichlorophenoxyacetic acid (2,4-D, herbicide biomarker) was associated with an 11.1 g increase in birth weight (95 % CI:1.0,21.1). In time-varying models, significant associations were identified for pyrethroid exposure measured between weeks 16–27, and for 2,4-D exposure measured during weeks 25–33. Organophosphates were not associated with birth weight. No associations were found for birth length or head circumference for any pesticide. In constant association models, a doubling of weekly 2,4-D was associated with a 0.05 week increase in gestational length (95 %CI:0.01,0.09); no associations were found with other biomarkers. Conclusions: We identified associations between gestational exposure to nonpersistent pesticides and both birth size and gestational length. Extending multiple informant models to account for the complex data structure allowed us to discern effects in opposing directions by distinct pesticide classes. While estimated effects for a given week were modest, prolonged or repeated exposures could result in larger cumulative impacts.http://www.sciencedirect.com/science/article/pii/S0160412025000431PesticidesInsecticidesBirth weightHerbicidesPregnancyPyrethroids |
| spellingShingle | Wylie BJ Kaali S Duttweiler L Ae-Ngibise KA Mujtaba M Tawiah C Gibson E Calafat AM Ospina M Jack DJ Agyei O Lee AG Roberts DJ Boamah-Kaali EA Factor-Litvak P Modest AM Hauser R Coull BA Asante KP Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models Environment International Pesticides Insecticides Birth weight Herbicides Pregnancy Pyrethroids |
| title | Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models |
| title_full | Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models |
| title_fullStr | Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models |
| title_full_unstemmed | Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models |
| title_short | Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models |
| title_sort | evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural ghana using a novel time varying extension of multiple informant models |
| topic | Pesticides Insecticides Birth weight Herbicides Pregnancy Pyrethroids |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025000431 |
| work_keys_str_mv | AT wyliebj evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT kaalis evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT duttweilerl evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT aengibiseka evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT mujtabam evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT tawiahc evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT gibsone evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT calafatam evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT ospinam evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT jackdj evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT agyeio evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT leeag evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT robertsdj evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT boamahkaaliea evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT factorlitvakp evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT modestam evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT hauserr evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT coullba evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels AT asantekp evaluationofgestationalnonpersistentpesticideexposurewithnewbornsizeandgestationallengthinruralghanausinganoveltimevaryingextensionofmultipleinformantmodels |