Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels
The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppresse...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000592 |
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| author | A. L. Pukhalsky M. S. Bliacher A. V. Danilina E. A. Kalashnikova T. K. Lopatina I. M. Fedorova |
| author_facet | A. L. Pukhalsky M. S. Bliacher A. V. Danilina E. A. Kalashnikova T. K. Lopatina I. M. Fedorova |
| author_sort | A. L. Pukhalsky |
| collection | DOAJ |
| description | The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan®). It is possible that the imunofan treatment could prevent some postvaccinal complications. |
| format | Article |
| id | doaj-art-dbd6eb9f6fd14fff9bd86e9464aaf331 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dbd6eb9f6fd14fff9bd86e9464aaf3312025-02-03T07:25:07ZengWileyMediators of Inflammation0962-93511466-18611996-01-015642943310.1155/S0962935196000592Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levelsA. L. Pukhalsky0M. S. Bliacher1A. V. Danilina2E. A. Kalashnikova3T. K. Lopatina4I. M. Fedorova5Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaMoscow Institute of Epidemiology and Microbiology, Moscow, RussiaNational Institute of Epidemiology, Moscow, RussiaResearch Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, RussiaMoscow Institute of Epidemiology and Microbiology, Moscow, RussiaMoscow Institute of Epidemiology and Microbiology, Moscow, RussiaThe effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan®). It is possible that the imunofan treatment could prevent some postvaccinal complications.http://dx.doi.org/10.1155/S0962935196000592 |
| spellingShingle | A. L. Pukhalsky M. S. Bliacher A. V. Danilina E. A. Kalashnikova T. K. Lopatina I. M. Fedorova Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels Mediators of Inflammation |
| title | Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels |
| title_full | Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels |
| title_fullStr | Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels |
| title_full_unstemmed | Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels |
| title_short | Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels |
| title_sort | changes in tnf and il 6 production after diphtheria toxoid vaccination drug modulation of the cytokine levels |
| url | http://dx.doi.org/10.1155/S0962935196000592 |
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