TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson’s disease

TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson’s disease

Abstract Cognitive impairment in Parkinson’s disease (PD) is a widespread and rapidly progressive feature that impacts prognosis. Although TREM2 has been implicated in neuroprotection across various neurodegenerative diseases, its specific role in PD remains to be clarified. In this study, we first...

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Main Authors: Baoyu Zhu, Jiezhu Feng, Xiaomei Liang, Zhongling Fu, Mengshi Liao, Tongtong Deng, Kaicheng Wang, Jianwei Xie, Jieshan Chi, Lu Yang, Yuyuan Gao, Kun Nie, Lijuan Wang, Piao Zhang, Yuhu Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02538-1
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