Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis

Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis

Abstract Background B cell immune dysregulation plays a critical role in myasthenia gravis (MG). However, targeted B-cell therapy such as rituximab may result in long-term peripheral B cell clearance and allow for the survival of plasma cells, contributing to frequent infections and relapses. Theref...

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Bibliographic Details
Main Authors: Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Myasthenia gravis
NIK
B cells
Therapeutic targets
Online Access:https://doi.org/10.1186/s12974-025-03342-5
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https://doi.org/10.1186/s12974-025-03342-5

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