Sex differences in the relationship between pain and autonomic outflow during a cold pressor test

Sex differences in the relationship between pain and autonomic outflow during a cold pressor test

Abstract Background Chronic pain is partly maintained by the sympathetic nervous system, whose activity is best measured by muscle sympathetic nerve activity (MSNA). MSNA responses to acute pain have been thoroughly investigated, whereas MSNA responses to longer-lasting pain are poorly understood. T...

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Main Authors: Laila A. Chaudhry, Yasmine Coovadia, Brittany K. Schwende, Danielle E. Berbrier, Will Huckins, Jinan Saboune, Derek A. Skolnik, Emily K. Van Berkel, Jeffrey S. Mogil, Charlotte W. Usselman
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biology of Sex Differences
Subjects:
Cold pressor test
Tonic pain
Muscle sympathetic nerve activity
Autonomic nervous system
Sex differences
Online Access:https://doi.org/10.1186/s13293-025-00743-2
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https://doi.org/10.1186/s13293-025-00743-2

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