Glycosylation Patterns in <i>Meccus (Triatoma) pallidipennis</i> Gut: Implications for the Development of Vector Control Strategies

Glycosylation Patterns in <i>Meccus (Triatoma) pallidipennis</i> Gut: Implications for the Development of Vector Control Strategies

The primary mode of transmission for Chagas disease is vector-borne transmission, spread by hematophagous insects of the <i>Triatominae</i> subfamily. In Mexico, the triatomine <i>Meccus pallidipennis</i> is particularly significant in the transmission of <i>Trypanosoma...

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Main Authors: Elia Torres-Gutiérrez, Frida Noelly Candelas-Otero, Olivia Alicia Reynoso-Ducoing, Berenice González-Rete, Mauro Omar Vences-Blanco, Margarita Cabrera-Bravo, Martha Irene Bucio-Torres, Paz María Silvia Salazar-Schettino
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Microorganisms
Subjects:
triatomine gut
glycosylation patterns
vector control
Chagas disease vector
Online Access:https://www.mdpi.com/2076-2607/13/1/58
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Summary:The primary mode of transmission for Chagas disease is vector-borne transmission, spread by hematophagous insects of the <i>Triatominae</i> subfamily. In Mexico, the triatomine <i>Meccus pallidipennis</i> is particularly significant in the transmission of <i>Trypanosoma cruzi</i>. This study focused on analyzing protein expression and modifications by glycosylation in different regions of the digestive tract of fifth-instar nymphs of <i>M. pallidipennis</i>. Two gut sections were dissected and extracted: the anterior midgut (AMG) and the proctodeum or rectum (RE). Proteins were extracted from each tissue sample and profiled by one- and two-dimensional electrophoresis; protein glycosylation was analyzed by lectin affinity. Our results showed significant differences in protein expression and glycosylation between both gut regions, with modifications being more frequent in the RE. The proteins HSP70, actin, and tubulin were analyzed, finding a differential expression of the latter two between AMG and RE. Understanding glycosylation patterns provides critical insights into vector–pathogen interactions that could eventually inform novel control approaches. Furthermore, the potential use of lectins as insecticidal agents highlights the broader implications of glycoprotein research in the future development of strategies on vector control to disrupt <i>T. cruzi</i> transmission.
ISSN:2076-2607

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