Genomic profile helps to predict the clonal evolution and outcome of BCR-ABL-negative myeloproliferative neoplasms

Genomic profile helps to predict the clonal evolution and outcome of BCR-ABL-negative myeloproliferative neoplasms

Classical BCR-ABL-negative myeloproliferative neoplasms (MPNs) are a clonal expansion of myeloid precursors caused by somatic stem cells. Although driver mutations were observed in most MPN patients, the potential clonal disorder remains unclear. We analyzed a total of 1004 newly diagnosed MPN patie...

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Bibliographic Details
Main Authors: Xiaodong Guo, Wenbo Jia, Xinyu Yang, Hexiao Jia, Hanyang Wu, Yihong Wei, Can Can, Na He, Hailei Zhang, Wancheng Liu, Shuang Yu, Daoxin Ma
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
Myeloproliferative neoplasms
Clonal evolution
Ruxolitinib
Somatic mutations
Overall survival
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332500172X
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