Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery
Interleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders. Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclero...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/247503 |
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| author | Francesco Maione Antonio Parisi Elisabetta Caiazzo Silvana Morello Fulvio D'Acquisto Nicola Mascolo Carla Cicala |
| author_facet | Francesco Maione Antonio Parisi Elisabetta Caiazzo Silvana Morello Fulvio D'Acquisto Nicola Mascolo Carla Cicala |
| author_sort | Francesco Maione |
| collection | DOAJ |
| description | Interleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders. Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and acute coronary syndrome and in the cardiovascular risk associated with systemic immunological disorders. Consistent with this, we have recently shown that IL-17A increases human and murine platelet response to ADP. In this study we expanded our previous observation and we describe for the first time an in vivo prothrombotic effect of the cytokine. Our results show that IL-17A is synergic with a low FeCl3 concentration in inducing carotid thrombus in rats and suggest that the effect is likely related to a downregulation of CD39 vascular expression and hydrolyzing activity. Our findings indicate that IL-17A might be an important molecule at the interface between hemostasis and inflammation. |
| format | Article |
| id | doaj-art-db70c246583e410aa5b2069aefdaaf1a |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-db70c246583e410aa5b2069aefdaaf1a2025-02-03T07:25:30ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/247503247503Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid ArteryFrancesco Maione0Antonio Parisi1Elisabetta Caiazzo2Silvana Morello3Fulvio D'Acquisto4Nicola Mascolo5Carla Cicala6Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, Fisciano, 84084 Salerno, ItalyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UKDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyInterleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders. Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and acute coronary syndrome and in the cardiovascular risk associated with systemic immunological disorders. Consistent with this, we have recently shown that IL-17A increases human and murine platelet response to ADP. In this study we expanded our previous observation and we describe for the first time an in vivo prothrombotic effect of the cytokine. Our results show that IL-17A is synergic with a low FeCl3 concentration in inducing carotid thrombus in rats and suggest that the effect is likely related to a downregulation of CD39 vascular expression and hydrolyzing activity. Our findings indicate that IL-17A might be an important molecule at the interface between hemostasis and inflammation.http://dx.doi.org/10.1155/2014/247503 |
| spellingShingle | Francesco Maione Antonio Parisi Elisabetta Caiazzo Silvana Morello Fulvio D'Acquisto Nicola Mascolo Carla Cicala Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery International Journal of Inflammation |
| title | Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery |
| title_full | Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery |
| title_fullStr | Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery |
| title_full_unstemmed | Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery |
| title_short | Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery |
| title_sort | interleukin 17a exacerbates ferric chloride induced arterial thrombosis in rat carotid artery |
| url | http://dx.doi.org/10.1155/2014/247503 |
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